纳米氢氧化镁材料对复配杀菌剂的增效作用及田间应用技术

Synergistic effect of compound fungicides by nano-Mg(OH)2 and field application technology

采用紫外分光光度计法,评估了一些杀菌剂对猕猴桃溃疡病菌的抑制活性,将两种活性较好的杀菌剂进行复配后,以纳米氢氧化镁为药物载体,研究了纳米氢氧化镁载体对复配杀菌剂的负载情况,并评估了纳米氢氧化镁对复配药物的抗猕猴桃溃疡病菌的影响,并对载体药物进行了田间应用效果研究。结果表明,测试的杀菌药剂都对猕猴桃溃疡病菌显示出一定的抑制活性,其中:复配药物-纳米氢氧化镁的抑菌活性最好,EC_(50)为23.50μg/mL,其次为复配药物,EC_(50)为42.11μg/mL。以纳米氢氧化镁作为药物载体,对药物的抗猕猴桃溃疡病菌有很好的协同作用,能提高药物的抑菌活性。另外,纳米氢氧化镁的含量对于载药量和包封率有显著影响。当氢氧化镁的含量从1 mg增加到3.5 mg时,载药量增加了43%,包封率增加了11%。此外,复配药物-纳米氢氧化镁载体剂对猕猴桃溃疡病有较好的田间防治效果,防效可达73.8%。

The inhibitory activity of some fungicides against kiwifruit canker was evaluated by ultraviolet spectrophotometer.Mixing two active fungicides,nano-magnesium hydroxide was used as the drug carrier to study loading capacity to the mixed fungicide.The synergistic effect nano-magnesium hydroxide on the anti-kiwifruit canker bacteria of the mixed compound fungicide was evaluated.Besides,the field application effect of compounded drugs loaded with nano-Mg(OH)_(2)was studied.The results showed that the tested bactericidal agents all showed a certain inhibitory activity against kiwifruit canker.Among them,the compound drug-nano-Mg(OH)_(2)had the best antibacterial activity with an EC_(50)of 23.50μg/mL,followed by the compound drug with an EC_(50)of 42.11μg/mL.The use of nano-magnesium hydroxide as the drug carrier has a good synergistic effect on the drug against kiwifruit canker.It can significantly improve the antibacterial activity of the drug.And the content of nano-Mg(OH)_(2)has a significant effect on drug loading and encapsulation efficiency.When the magnesium hydroxide content was increased from 1 mg to 3.5 mg,the drug loading increased by 43%and the encapsulation efficiency increased by 11%.In addition,the compound drug-nano-Mg(OH)_(2)carrier agent has a good field control effect on kiwifruit canker,and the control effect can reach 73.8%.