微生物代谢工程生产L-酪氨酸研究进展

Advances in production of L-tyrosine through microbial metabolic engineering

L-酪氨酸是一种具有重要营养功能的芳香族氨基酸,在食品、饲料、医药以及化工等行业具有广泛的应用。通常生产L-酪氨酸的方法有化学合成法、水解法和代谢工程改造微生物合成法。相较于前2种方法的众多缺陷,代谢工程改造微生物合成L-酪氨酸越来越广泛被利用。该文综述了利用代谢工程改造微生物提高L-酪氨酸产量的方法,以期为相关科研者提供一定的思路。

L-tyrosine is an aromatic amino acid with significant nutritional functions,widely utilized in the food,feed,medicine,and chemical industries.Generally,the methods for producing L-tyrosine include chemical synthesis,hydrolysis,and metabolic engineering of modified microorganisms through metabolic engineering.Compared to the numerous drawbacks of the first two methods,metabolic engineering for modifying microorganisms to synthesize L-tyrosine is increasingly being widely used.This article reviewed the methods of using metabolic engineering to modify microorganisms to increase L-tyrosine production,providing insights for researchers in the field.