IRF9、PSMA5联合外周血巨噬细胞M1/M2极化状态预测类风湿性关节炎进展的多元回归模型

Multiple Regression Model of IRF9,PSMA5 Combined with M1/M2 Polarization Status of Peripheral Blood Macrophages to Predict Rheumatoid Arthritis Progression

目的探究干扰素调节因子9(IRF9)、蛋白酶体a5亚基(PSMA5)联合外周血巨噬细胞经典激活(M1)和替代激活(M2)极化状态对类风湿性关节炎(RA)进展的预测价值。方法选取2022年2月—2023年2月齐齐哈尔医学院附属第三医院收治的87例RA患者,根据疾病严重程度将其分为活动期组和缓解期组。比较两组患者IRF9、PSMA5、M1/M2比值,采用二元Logistic回归分析其与RA进展的关系,构建风险预测模型,利用ROC曲线、校准曲线与决策曲线评价其预测价值。结果缓解期组共49例患者(56.32%),活动期组共38例患者(43.68%),两组在累及关节数、关节压痛指数及关节肿胀指数等方面,差异有统计学意义(P<0.05);活动期患者IRF9、PSMA5、M1、M1/M2比例显著高于缓解期组,但M2显著低于缓解期组,差异有统计学意义(P<0.05);Logistic回归分析显示IRF9、PSMA5、M1/M2比值是RA疾病进展的危险因素;ROC分析用于预测RA进展,AUC值显示M1/M2为0.690,IRF9为0.664,PSMA5为0.733。结论M1/M2、IRF9、PSMA5与RA疾病进展相关,有助于评估RA疾病进展。

Objective To study the predictive value of IRF9 and PSMA5 combined with M1 and M2 macrophage polarization on rheumatoid arthritis(RA)progression.Methods A total of 87 RA patients were divided into active and remission groups based on disease severity.IRF9 and PSMA5 expression,M1 and M2 macrophage proportions,and the M1/M2 ratio were compared.Logistic regression and ROC analysis were used to assess predictive performance.Results Higher expression of IRF9 and PSMA5 was seen in active RA patients.M1/M2 ratio was higher in active RA.Logistic regression identifi ed IRF9,PSMA5,and M1/M2 ratio as RA progression risk factors.AUC values for predicting RA progression were 0.690 for M1/M2,0.664 for IRF9,and 0.733 for PSMA5.Conclusion M1/M2 polarization,IRF9,and PSMA5 levels were elevated in RA patients and correlated with disease progression.These markers could be valuable for assessing and evaluating RA progression clinically.