五行针灸治疗原发性失眠的疗效及对免疫功能、神经递质的影响

Curative effect of five-element acupuncture in the treatment of primary insomnia and its influence on immune function and neurotransmitter

目的探究五行针灸治疗原发性失眠的疗效及对免疫功能、神经递质的影响。方法选取原发性失眠患者92例为研究对象,按照随机数字表法分为治疗组46例、对照组46例。对照组予以艾司唑仑片治疗,治疗组在对照组基础上联合五行针灸治疗,均治疗4周。比较2组疗效,比较2组治疗前、治疗2周和治疗4周阿森斯失眠量表(AIS)评分,比较2组治疗前后γ-氨基丁酸(GABA)、5-羟色胺(5-HT)、肿瘤坏死因子α(TNF-α)、核因子κB(NF-κB)水平及单核细胞计数、淋巴细胞计数、白细胞计数、CD4^(+)/CD8^(+)水平。结果2组疗效比较差异有统计学意义(Z=2.030,P<0.05),治疗组临床疗效优于对照组,总有效率高于对照组(P<0.05)。2组治疗2、4周时AIS评分均低于本组治疗前(P<0.05),治疗4周时AIS评分低于治疗2周时(P<0.05),且治疗组治疗2、4周AIS评分均低于对照组同期(P<0.05)。治疗后,2组5-HT、GABA水平高于本组治疗前(P<0.05),TNF-α、NF-κB水平低于本组治疗前(P<0.05),且治疗后2组组间比较差异也均有统计学意义(P<0.05)。治疗后2组单核细胞计数、淋巴细胞计数、白细胞计数较本组治疗前降低(P<0.05),CD4^(+)/CD8^(+)较本组治疗前升高(P<0.05),且治疗后2组组间比较差异也均有统计学意义(P<0.05)。结论五行针灸治疗原发性失眠具有较好的临床疗效,可有效改善失眠症状,提高免疫功能,调节神经递质分泌。

Objective To explore the effect of five-element acupuncture on primary insomnia(PI)and its influence on immune function and neurotransmitters.Methods A total of 92 PI patients were randomly assigned into treatment group(n=46)and control group(n=46).All patients were managed by estazolam tablets,and those in treatment group were additionally treated with five-element acupuncture.Treated for 4 weeks,the aim was to compare clinical effect,Athens Insomnia Scale(AIS)score on day 0,and at weeks 2 and 4,gamma-aminobutyric acid(GABA),5-hydroxytryptamine(5-HT),tumor necrosis factor alpha(TNF-α),nuclear factor kappa B(NF-κB),monocyte count,lymphocyte count,white blood cell(WBC)count,CD4^(+)/CD8^(+).The curative effect was assessed.Results The overall effective rate in the treatment group was better than that in the control group(Z=2.030,P<0.05).AIS scores at weeks 2 and 4 in the both groups were significantly lower than those before treatment(P<0.05),which in the treatment group were significantly lower than those of the control group(P<0.05).AIS scores at week 4 in the both groups were significantly lower than those at week 2(P<0.05).After treatment,significantly increased 5-HT and GABA,and significantly decreased TNF-αand NF-κB were found in the both groups than those before treatment(all P<0.05),and the different was significant between groups for the above indexes(all P<0.05).After treatment,significantly decreased counts of monocyte,lymphocyte and WBC,and significantly increased level of CD4^(+)/CD8^(+)were detected in the both groups than those before treatment(all P<0.05),and the different was significant between groups for the above indexes(all P<0.05).Conclusion Five-element acupuncture has good clinical efficacy in PI patients,which can effectively improve insomnia symptoms,enhance immune function,and improve neurotransmitters.