虾青素的生殖保护及在围产医学中作用的研究进展

Research progress on the reproductive protection of astaxanthin and its role in perinatal medicine

虾青素是一种叶黄素类胡萝卜素,具有抗氧化、抗炎、抗肿瘤、保护神经及心血管系统等多种药理和生物活性,已成为食品、营养品和医药等领域的高需求天然产物及研究热点.目前,越来越多的研究证据表明虾青素具有良好的生殖保护作用,包括治疗多囊卵巢综合征、卵巢癌、子宫内膜异位症及生殖系统炎症等引起的女性生殖系统功能损伤,且可增加辅助生殖治疗的成功率.此外,虾青素在防治子痫前期及妊娠期糖尿病等多种围产疾病方面也显示出了独特的优势.本文对虾青素在生殖保护及在围产医学中应用现状及其作用机制进行综述.

Astaxanthin(AXT)is a lutein carotenoid with various pharmacological and biological activities,including antioxidant,anti-inflammatory,anti-tumor,and neurological and cardiovascular system protection.AXT has become a high-demand natural product.Increasing evidence has suggested that AXT was effective for the treatment of female reproductive system impairment caused by polycystic ovary syndrome,ovarian cancer,endometriosis,and reproductive system inflammation.AXT has also been shown to increase the success rate of assisted reproductive therapy.In addition,AXT has been demonstrated great advantages in the prevention and treatment of various perinatal diseases such as preeclampsia and gestational diabetes.Here,we review the latest progress in the therapeutic effects of AXT and the underlying mechanism.