肝细胞癌转化治疗的策略及实践

Strategies and practice of conversion therapy for hepatocellular carcinoma

原发性肝癌因发病隐匿及预后较差,多数初始诊断即为不可切除。近些年,随着靶向治疗、免疫治疗及局部治疗等转化治疗方案的兴起,部分中晚期肝癌患者成功转化并行根治性手术切除,但同时也带来了诸多问题,如潜在转化人群的界定、转化方案的选择、转化后手术切除的必要性及时机、转化手术后辅助治疗的必要性及持续时间等。本文将结合笔者的自身经验,针对肝癌转化治疗中上述问题进行探讨。

Due to the insidious onset and poor prognosis of primary liver cancer,most patients are found to have unresectable primary liver cancer at initial diagnosis.In recent years,with the advent of targeted therapy,immunotherapy,and local therapy,some patients with advanced liver cancer have achieved successful conversion and undergone radical surgical resection,but at the same time,such treatment has brought many issues,such as the identification of potential population for conversion,the selection of conversion regimen,the necessity and timing of surgical resection after conversion,and the necessity and duration of adjuvant therapy after conversion surgery.This article discusses the above problems in conversion therapy for liver cancer based on the author’s own experience.