音乐疗法对卒中后认知功能障碍的疗效研究——Meta分析

Effect of Music Therapy on Cognitive Impairment after Stroke:A Meta-Analysis

目的:评价音乐疗法对卒中后认知功能障碍的干预效果。方法:检索中英文电子数据库中有关音乐疗法对卒中后认知功能障碍患者的干预效果的随机对照试验研究,利用Revman5.4软件进行Meta分析。结果:共纳入15篇文献,涉及1229例患者。Meta分析结果显示,MoCA(2019年前发表组)合并效应量结果MD=2.91,95%CI 2.57~3.25,P<0.00001、MoCA[2019年后(含2019年)发表组]合并效应量结果MD=4.62,95%CI 4.23~5.02,P<0.00001、MMSE[MD=4.49,95%CI为(0.81~8.18),P<0.00001];Stroop色词测验[MD=5.17,95%CI 2.99~7.35,P<0.00001]、HAMA[MD=-4.55,95%CI-5.16~-3.93,P<0.00001]、HAMD[MD=-6.02,95%CI-6.84~-5.20),P<0.00001]。结论:音乐疗法能改善卒中后认知功能障碍及情绪。

Objective:To evaluate the effect of music therapy on cognitive dysfunction after stroke.Methods:Randomized controlled trials studying the effects of music therapy for poststroke cognitive dysfunction were retrieved from Chinese and English electronic databases,and meta-analysis was performed using RevMan 5.4 statistical software.Results:A total of 15 articles with 1229 patients were included.The meta-analysis results revealed that for the Montreal Cognitive Assessment(MoCA),the pooled effect size was MD=2.91,95%CI(2.57,3.25),P<0.00001 for studies published before 2019,and MD=4.62,95%CI(4.23,5.02),P<0.00001 for those published in or after 2019.Significant improvements were also found in the pooled Mini-Mental State Examination(MMSE)[MD=4.49,95%CI(0.81,8.18),P<0.00001],Stroop Color and Word Test[MD=5.17,95%CI(2.99,7.35),P<0.00001],Hamilton Anxiety Scale(HAMA)[MD=-4.55,95%CI(-5.16,-3.93),P<0.00001],and Hamilton Depression Scale(HAMD)[MD=-6.02,95%CI(-6.84,-5.20),P<0.00001].Conclusion:Music therapy can significantly improve cognitive dysfunction and emotional state in stroke survivors.