食欲素治疗抑郁失眠共病的研究进展

Research Progress on Orexin Treatment for Comorbid Depression and Insomnia

抑郁是以心情低落为主要特征的一种常见精神疾病,在临床实际接触中抑郁患者往往伴有失眠症状,尤其是在经历过新冠肺炎疫情大流行后,生活和工作的双重压力下失眠及抑郁更是当下常见的精神障碍类疾病,往往是两种症候并存。以往的治疗中抗抑郁、抗失眠药物联合使用可以达到治疗抑郁失眠的作用,但副作用大,使用限制多,故研究两者共同靶点,寻找抑郁失眠共病新治疗方法是当下急需的。本文围绕食欲素及其受体信号通路、脑区分布等方面探析,综合论述食欲素与失眠、抑郁共病之间的联系及可能涉及的作用靶点、机制通路,思考从食欲素治疗抑郁失眠共病的可能性,以期为食欲素的开发与应用提供参考,更好地解决抑郁失眠共病问题。

Depression is a common mental disorder primarily characterized by a persistent low mood.Clinically,patients with depression often suffer from insomnia,which has become more prevalent since the COVID-19 pandemic due to the dual pressures of life and work.Insomnia and depression frequently cooccur as dual symptoms.Traditional treatments involving a combination of antidepressant and anti-insomnia medications can be effective,but they have significant adverse effects and numerous usage limitations.Therefore,there is an urgent need for research into the shared targets of both conditions and the development of new therapeutic approaches for comorbid depression and insomnia.This review explores the role of orexin,its receptor signaling pathway and its distribution in the brain,and discusses the connections between orexin and the comorbidity of insomnia and depression,along with potential targets and mechanisms.This article highlights the possibility of orexin in treating comorbid depression and insomnia,aiming to provide a reference for the development and application of orexin,and to better address the issue of comorbid depression and insomnia.