心电图复极参数、血清SIRT6水平在急性心肌梗死患者疗效中的变化及其临床价值

Changes of ECG repolarization parameters and serumSIRT6 levels in patients with acute myocardialinfarction and their clinical value

目的:分析心电图复极参数、血清沉默信息调节因子6(SIRT6)水平在急性心肌梗死患者疗程中的变化,并探究其临床价值。方法:选取2021年10月至2023年12月河南中医药大学第三附属医院收治的经PCI治疗的急性心肌梗死患者为研究组(n=136),另选取同期健康体检者为对照组(n=136),根据患者术后半年不同预后疗效情况分为预后不良患者及预后良好患者;对比两组入院时心电图复极参数、血清SIRT6水平;对比不同预后患者入院时及治疗3 d、7 d、14 d时心电图复极参数、血清SIRT6水平;ROC分析治疗14 d时心电图复极参数、血清SIRT6水平对预后不良的预测价值。结果:研究组入院时心电图复极参数均高于对照组,血清SIRT6表达显著低于对照组(P<0.05);预后不良患者入院时、治疗3 d、7 d、14 d时心电图复极参数显著高于预后良好患者,血清SIRT6显著低于预后良好患者(P<0.05);治疗14 d时心电图复极参数、血清SIRT6水平联合预测预后不良的AUC为0.784,最佳敏感度、特异度分别为71.79%、79.59%。结论:心电图复极参数、血清SIRT6水平与患者预后疗效显著相关,临床可通过检测其水平预测患者预后疗效。

Objective:To analyze the changes of ECG repolarization parameters and serum silencing information regulatory factor 6(SIRT6)levels in patients with acute myocardial infarction during the course of treatment,and to explore their clinical value.Methods:Patients with acute myocardial infarction admitted to The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from October 2021 to December 2023 were selected as the study group(n=136),and healthy subjects in the same period were selected as the control group(n=136).According to the different prognosis and efficacy of the patients six months after surgery,the patients were divided into patients with poor prognosis and patients with good prognosis.Ecg repolarization parameters and serum SIRT6 levels were compared between the two groups at admission.Ecg repolarization parameters and serum SIRT6 levels of patients with different prognosis were compared at admission and at 3,7 and 14 days after treatment.ROC analysis of ECG repolarization parameters and serum SIRT6 level in the prediction of poor prognosis after 14 days of treatment.Results:The ECG repolarization parameters of the study group were higher than those of the control group,and the serum SIRT6 expression was significantly lower than that of the control group(P<0.05).Ecg repolarization parameters of patients with poor prognosis were significantly higher than those of patients with good prognosis at admission,3,7 and 14 days of treatment,and serum SIRT6 was significantly lower than those of patients with good prognosis(P<0.05).After 14 days of treatment,the combined prediction of AUC for poor prognosis of ECG repolarization parameters and serum SIRT6 level was 0.784,and the best sensitivity and specificity were 71.79%and 79.59%,respectively.Conclusion:Electrocardiogram repolarization parameters and serum SIRT6 level are significantly related to the prognosis of patients,and the prognosis of patients can be predicted by detecting their levels.