老年患者利奈唑胺相关贫血的危险因素分析

Analysis of risk factors for lenalidomide-related anemia in elderly patients

目的 分析老年患者利奈唑胺相关贫血的危险因素。方法 收集2020年1月1日至2022年12月31日在内蒙古自治区人民医院接受利奈唑胺治疗的老年患者资料,分为贫血组及非贫血组,比较两组患者的人口统计学特征、感染部位、感染指标、是否接受连续肾脏替代治疗、快速序贯器官衰竭评估(quick sequential organ failure assessment,qSOFA)评分、实验室检查指标、肾小球滤过率估算值(estimated glomerular filtration rate,eGFR)以及用药情况等差异。通过多因素logistic回归分析老年患者利奈唑胺相关贫血的独立危险因素。结果 共纳入104例患者,贫血组19例(18.3%),非贫血组85例(81.7%)。多因素logistic回归发现用药疗程(P=0.003)、eGFR(P=0.008)及qSOFA评分(P=0.002)是发生利奈唑胺相关贫血的独立危险因素。结论 老年患者利奈唑胺相关贫血与用药疗程、eGFR及qSOFA评分有关,临床应予以重视。

Objective To analyze risk factors for linezolid-induced anemia in elderly patients.Methods The elderly patients receiving linezolid treatment in Inner Mongolia Autonomous Region People's Hospital from January 1,2020 to December 31,2022 were collected.The patients were divided into the anemia group and the non-anemia group.The demographic characteristics,infection site,infection indicators,whether continuous renal replacement therapy was received,quick sequential organ failure assessment(qSOFA)score,laboratory test indicators,estimated glomerular ffltration rate(eGFR),and drug use in the two groups were compared.Multivariate logistic regression was used to analyze the independent risk factors of linezolid-related anemia in elderly patients.Results A total of 104 patients were included,with 19 cases(18.3%)in the anemic group and 85 cases(81.7%)in the non-anemic group.Multivariable logistic regression identiffed duration of medication(P=0.003),eGFR(P=0.008),and qSOFA score(P=0.002)as independent risk factors for linezolid-induced anemia.Conclusion Linezolid-induced anemia in elderly patients is associated with duration of medication,eGFR,and qSOFA score,which should be paid attention to clinical application.