肽-钙螯合方式及吸收机制研究现状

Research Status of Peptide-Calcium Chelation and Absorption Mechanism

钙是人体必需的常量元素之一,科学补钙对维持生命健康具有重要意义,具有良好钙结合能力和高生物利用度的肽-钙螯合物也备受关注。本文综述了肽-钙螯合物中钙与肽的结合位点、结合模式、分子间作用力等内容。通过阐明游离钙和螯合钙的吸收途径,分析螯合钙易被肠道吸收的特点。肽-钙螯合物作为新型钙补充剂,来源丰富且生物利用度高,具有良好的经济开发价值和广阔的发展前景。在肽-钙螯合物的安全性、物理化学稳定性、消化稳定性以及螯合钙被肠道吸收后Ca^(2+)的释放机制等方面的研究需要继续开展。本文旨在为新型钙补充剂的开发提供思路。

Calcium is one of the essential macro-elements in the human body.The scientific calcium supplementation is greatly significant to maintaining life and health.The peptide-calcium chelates with good calcium binding capacity and high bioavailability have attracted more attention.This work reviews the binding sites,binding modes,and intermolecular forces between calcium and peptides in peptide-calcium chelates.Compared with free calcium,chelated calcium is more easily absorbed in the intestine according to the summarization of the calcium absorption pathways.Peptide-calcium chelates,as a new generation of calcium supplements,have a rich source of raw materials,high bioavailability,good economic value,and broad development prospects.Further research is needed on the safety,physicochemical stability,digestive stability,and Ca^(2+) release mechanism of peptide-calcium chelates after intestinal absorption.This paper aims to provide new insight into the development of novel calcium supplements.