离子淌度质谱在食品分析中的应用

Application of Ion Mobility Mass Spectrometry in Food Analysis

离子淌度谱是一种以样品离子在电场和气流共同作用下发生迁移时的差异来表征化合物的技术,可根据离子的电荷数、质量、尺寸以及形状对其进行分离,同时还可以通过计算出离子的碰撞横截面积,从而获得化合物的结构信息,在分离物质的同分异构体方面表现出优异的性能。近年来,多种离子淌度技术相继出现,并与质谱技术相联合广泛应用于食品、生物、医药、环境等领域。本文介绍了离子淌度谱技术的种类和工作原理,分析了不同种类技术当前存在的优势和缺陷,综述了离子淌度谱和液相、质谱等多维联用在分析鉴定食品营养活性成分和食品化学危害物中的应用,并对该技术的应用前景和发展趋势进行了展望。

Ion mobility spectroscopy is a technique to characterize compounds based on the differences in the migration of sample ions under the combined action of electric field and air flow.Ions can be separated according to their quantity of electric charge,mass,size and shape.Meanwhile,the collision cross section of the ions can also be calculated to obtain chemical compound structural information,which has shown excellent performance in separating isomers of substances.In recent years,a variety of ion mobility technologies combined with mass spectrometry technology have emerged,and been widely used in food,biology,medicine,environment and other fields.In this paper,the types and working principles of ion mobility spectroscopy are introduced,the advantages and disadvantages of various types of instruments are analyzed,and the application of ion mobility spectrometry,liquid chromatography and mass spectrometry multidimensional combination in analyzing and identifying nutritive and active ingredients and chemical hazards in food is reviewed.The application prospect and development trend of this technology are also prospected.