左侧M1区间歇短阵脉冲刺激对脑卒中患者脑功能网络拓扑属性的影响

The left M1 intermittent theta burst stimulation(iTBS)modulated the topological properties of the brain functional network in stroke patients

目的:探索间歇短阵脉冲刺激(intermittent theta burst stimulation,iTBS)这一新型无创神经调控技术对脑卒中患者脑功能网络拓扑结构的总体调控作用。方法:本研究纳入存在运动和语言障碍的脑卒中患者16例,利用静息态功能磁共振数据,分析受试者接受单次左侧M1区iTBS前、后,全脑功能网络集群系数、特征路径长度、局部和全局效率、“小世界”属性、同配性和层级性等拓扑属性的变化。结果:经上述iTBS干预后,受试者脑功能网络的集群系数、局部效率、标准化的层级系数显著下降,全局效率下降接近显著,“小世界”属性σ值升高接近显著,其他拓扑参数未见显著变化。结论:本研究初步揭示了左侧M1区iTBS对于脑卒中患者功能网络的全局拓扑结构可能发生调控作用。

Objective:To explore the overall modulatory effect of the intermittent theta burst stimulation(iTBS),a novel non-invasive brain stimulation technique,on the topology of the brain functional network in stroke patients.Method:Sixteen patients with stroke were recruited.Based on their brain resting-state functional magnetic resonance images,the changes of the brain network topological properties,including the clustering coefficient,characteristic path length,local and global efficiency,"small-world",assortativity and hierarchy,were analyzed before and after one session of left M1 iTBS.Result:The clustering coefficient,local efficiency and normalized hierarchy coefficient decreased significantly after one session of the iTBS,the global efficiency decreased near significantly,and the value of"smallworld"increased close to significantly;while the other topological properties showed no significant change following the iTBS intervention.Conclusion:The findings of the present study indicated that the left M1 iTBS may modulate the global network topological characteristics of the brain functional network in patients with stroke.