雌激素受体在卵巢癌中作用的研究进展

Estrogen receptor-mediated transactivation in ovarian cancer

雌激素受体(estrogen receptor,ER)是核受体超家族的重要成员,主要以雌激素依赖的方式介导下游靶基因的表达,并受到辅助调节因子和非编码RNA等的调控。诸多研究揭示,ERs介导的基因表达调控在上皮性卵巢癌和卵巢颗粒细胞瘤的发生与发展中起到重要作用,特别是子宫内膜样卵巢癌。本文主要综述了近年来新发现的辅助调节因子与非编码RNA在ERs介导转录调控中的作用、ERs的靶基因以及ERs在子宫内膜异位症向其相关卵巢癌进展过程中的作用。本文旨在进一步总结ERs的生物学功能及其在上述类型的卵巢癌发病机制中的作用,并为开发新的内分泌治疗策略提供思路与启示。

Estrogen receptor(ER)is a crucial member of the nuclear receptor superfamily,playing a significant role in modulating the expression of target gene that can be regulated by co-regulatory factors and non-coding RNAs.Numerous studies have revealed that ERs-mediated transactivation is associated with the development of epithelial ovarian cancer and ovarian granulosa cell tumor,especially endometrioid ovarian cancer.Our review aims to summarize the newly discovered roles of co-regulatory factors,non-coding RNAs and the target genes in ERs-mediated transactivation,as well as the involvement of ERs in the progression of endometriosis to endometriosisassociated ovarian cancer.We believe this will provide insight into understanding the pathogenesis of those ovarian cancers and developing novel endocrine therapy strategies.