SIRT6在横纹肌代谢及相关疾病中的研究进展

Research progress of SIRT6 in striated muscle metabolism and related diseases

SIRT6是一种染色质相关的NAD+依赖性酶,广泛表达于哺乳动物的所有组织中,在维持生命健康中发挥着至关重要的作用。横纹肌(骨骼肌和心肌)作为人体的重要组成部分,承担着能量代谢、姿势维持以及推动血液流动等多重功能,对维持机体生命活动至关重要;当横纹肌代谢紊乱时,可能引发一系列横纹肌疾病,如骨骼肌萎缩和心肌肥大等。近年来研究显示,SIRT6参与横纹肌相关功能调控。本综述旨在深入探讨SIRT6在横纹肌生理和病理状态下的调控机制及其生理功能,以期为相关领域的基础研究和疾病防治提供新的思路和策略。

Sirtuin6(SIRT6)is a chromatin-associated NAD+-dependent enzyme widely expressed in all mammalian tissues and plays a crucial role in maintaining life and health.As an important part of the human body,striated muscle(skeletal and cardiac muscle)assumes multiple functions such as energy metabolism,postural maintenance,and promotion of blood flow,and striated muscle is crucial in maintaining activities of the organisms.When striated muscle metabolism is disturbed,a series of disorders may be triggered,such as skeletal muscle atrophy and cardiac muscle hypertrophy.Recent studies have shown that SIRT6 is involved in the regulation of the biological functions of striated muscle.This review explores the mechanism of SIRT6 in the physiological and pathological states of striated muscle,aiming to provide new ideas and strategies for basic research and for disease prevention and treatment.