多发性骨髓瘤患者运动干预的最佳证据总结

Summary of the best evidence for exercise intervention in patients with multiple myeloma

目的总结国内外多发性骨髓瘤患者运动干预的相关证据,为医护人员制订运动干预方案提供循证依据。方法通过循证护理的方法,系统检索国内外相关指南网站、专业协会网站以及数据库中与多发性骨髓瘤患者运动干预相关的文献,包括最佳实践、推荐实践、指南、专家共识、证据总结、系统评价。检索时限为建库至2024年4月16日。由2名研究者对文献进行质量评价并提取资料。采用JBI证据预分级及证据推荐级别系统(2014版)确定证据条目等级和推荐等级。结果最终纳入文献15篇,其中临床决策1篇、指南4篇、系统评价8篇、专家共识1篇、证据总结1篇。汇总证据共26条,包括适用人群、运动评估、运动方案、运动注意事项和运动管理5个方面。结论总结出的证据多发性骨髓瘤患者运动干预的制订与管理提供了依据,建议医护人员应用证据时充分考虑临床情景,结合患者状态及偏好制订个性化的运动干预方案。

Objective To summarize the relevant evidence of exercise intervention for patients with multiple myeloma at home and abroad,and provide evidence-based basis for medical staff to formulate exercise intervention programs.Methods Through the method of evidence-based nursing,the literatures related to exercise intervention for patients with multiple myeloma were systematically retrieved from relevant guideline websites,professional association websites and databases at home and abroad,including best practices,recommended practices,guidelines,expert consensus,evidence summary,systematic reviews and so on.The search time limit was established until April 16,2024.Two researchers evaluated the quality of the literature and extracted the data.JBI pre-classification of evidence and level of Recommendation system(2014 version)was used to determine the level of evidence items and recommendation level.Results A total of 15 articles were included,including 1 clinical decision,4 guidelines,8 systematic reviews,1 expert consensus and 1 evidence summary.A total of 26 pieces of evidence were summarized,including 5 aspects,including applicable population,exercise evaluation,exercise plan,exercise precautions and exercise management.Conclusions The best evidence summarized in this study provides a basis for the development and management of exercise intervention in patients with multiple myeloma.It is suggested that clinical staff should fully consider the clinical context when applying the evidence,and develop personalized exercise intervention programs based on the patient′s status and preferences.