西藏地区藏族人群胰腺脂肪浸润影响因素分析

Analysis of risk factors for pancreatic fatty infiltration in the Tibetan population in Xizang

目的:分析西藏地区藏族人群胰腺脂肪浸润的临床特征,探讨胰腺脂肪浸润的相关影响因素。方法:采用病例对照研究,回顾性分析西藏自治区人民医院2013年1月至2023年12月通过影像学检查诊断为胰腺脂肪浸润的藏族患者103例的临床资料(病例组),同时随机抽取该院相同时间内影像学检查中没有被诊断为胰腺脂肪浸润藏族患者103例为对照组,比较两组间各项临床指标的差异。结果:103例胰腺脂肪浸润藏族患者男女比例约为1∶0.6;发病年龄为(63.14±13.95)岁;职业以公职人员为主,54例(52.94%)。两组年龄、职业,伴有非酒精性脂肪肝、慢性胃炎、胆囊结石、胆囊炎、糖尿病、高血脂、动脉粥样硬化、高血压、高尿酸血症、肥胖症,临床症状等差异均有统计学意义(均P<0.05)。经多因素logistic回归分析显示,年龄(OR=4.87,P=0.010)、肥胖症(OR=20.90,P=0.049)是胰腺脂肪浸润的独立危险因素,而农民(OR=0.05,P<0.001)是胰腺脂肪浸润的保护因素。结论:胰腺脂肪浸润多见于男性,多发生于中老年公职人群。年龄、肥胖症是胰腺脂肪浸润的独立危险因素,相比其他职业,农民是胰腺脂肪浸润的保护因素。

Objective To analyze the clinical characteristics of pancreatic fatty infiltration in the Tibetan population in Xizang and investigate the factors influencing pancreatic fatty infiltration.Methods A case-control study was performed to retrospectively analyze the clinical data of 103 Tibetan patients diagnosed with pancreatic fatty infiltration through imaging examinations at the People's Hospital of Xizang Autonomous Region between January 2013 and December 2023(patient group).Additionally,103 Tibetan patients who were not diagnosed with pancreatic fatty infiltration during the same period at the same hospital were randomly selected and included in the control group.The clinical indicators were compared between the two groups.Results The male-to-female ratio among the 103 Tibetan patients with pancreatic fatty infiltration was approximately 1:0.6.The average age of onset was(63.14±13.95)years,and the predominant occupation was public officials,accounting for 54 cases(52.94%).The differences in age,occupation,and the presence of non-alcoholic fatty liver,chronic gastritis,gallbladder stones,cholecystitis,diabetes mellitus,hyperlipidemia,atherosclerosis,hypertension,hyperuricemia,and obesity,as well as clinical symptoms between the two groups,were statistically significant(all P<0.05).Multivariate logistic regression analysis showed that age(OR=4.87,P=0.010)and obesity(OR=20.90,P=0.049)were independent risk factors for pancreatic fatty infiltration,while being a farmer(OR=0.05,P<0.001)was a protective factor against pancreatic fatty infiltration.Conclusion Pancreatic fatty infiltration is more common in men than in women and is primarily observed in middle-aged and older adult public officials.Age and obesity are independent risk factors for pancreatic fatty infiltration,while being a farmer is a protective factor compared with other occupations.