不同身体质量指数对子宫内膜癌患者预后的影响研究

Effect of different body mass index categories on the prognosis of endometrial cancer in patients

目的:探讨子宫内膜癌患者不同身体质量指数(body mass index,BMI)对其预后的影响。方法:选取建德市第一人民医院2018年1月至2023年6月收治的子宫内膜癌患者100例,根据不同BMI分为正常组(18.50~<25.00 kg/m^(2))、超重组(25.00~30.00 kg/m^(2))、肥胖组(>30.00 kg/m^(2))。分析BMI对子宫内膜癌患者预后的影响。结果:不同BMI患者的年龄差异均有统计学意义(均P<0.05),与正常组相比,超重、肥胖组年龄更小。Kaplan-Meier生存分析显示,不同BMI对总生存期(overall survival,OS)无明显影响。经单因素分析,年龄小、肿瘤高分期、深部肌层浸润、盆腔淋巴结阳性患者OS较短(均P<0.05)。多因素Cox回归分析显示,年龄对子宫内膜癌患者预后具有一定影响(RR=3.438,95%CI:1.404~8.421,P<0.05)。结论:BMI对患者预后无明显影响,但高BMI子宫内膜癌患者年龄相对偏小,可能是影响预后的重要因素,仍需进一步探讨。

Objective To investigate the effect of different body mass index categories on the prognosis of endometrial cancer in patients.Methods A total of 100 patients with endometrial cancer who received treatment at the First People's Hospital of Jiande from January 2018 to June 2023 were included in this study.Based on different body mass index categories,they were divided into a normal group(18.50-<25.00 kg/m^(2)),an overweight group(25.00-30.00 kg/m^(2)),and an obese group(>30.00 kg/m²).The effect of body mass index on the prognosis of endometrial cancer was analyzed.Results The age differences among patients with different body mass index categories were statistically significant(all P<0.05).Compared with the normal group,the age of patients in the overweight and obese groups was younger.Kaplan-Meier survival analysis showed that different body mass index categories had no significant effect on overall survival.Univariate analysis revealed that patients who were younger,had advanced tumor stages,exhibited deep muscular layer infiltration,and tested positive for pelvic lymph nodes exhibited significantly shorter overall survival compared with those without these factors(all P<0.05).Multivariate Cox regression analysis showed that age had a certain effect on the prognosis of endometrial cancer in patients(RR=3.438,95%CI:1.404-8.421,P<0.05).Conclusion Body mass index has no significant effect on the prognosis of endometrial cancer.Patients who are diagnosed with endometrial cancer and have a higher body mass index tend to be notably younger than those with a lower body mass index,which could potentially be a critical factor influencing their prognosis.This needs further investigation.