五灵胶囊防治精神类药物致肝损伤的作用及对患者睡眠质量的影响

Effect of Wuling Capsules on preventing and treating liver injury caused by psychotropic drugs and its impact on patients’sleep quality

目的 探讨五灵胶囊防治精神类药物致肝损伤的作用及对患者睡眠质量的影响。方法 将2021年1月—2023年12月收治的使用精神类药物的抑郁症患者240例作为研究对象,用随机数字表法分为对照组和观察组,每组120例。对照组用盐酸度洛西汀肠溶胶囊治疗,观察组在对照组治疗的基础上加用五灵胶囊治疗。治疗12周后,比较2组主要肝功能指标[丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)、谷氨酰转肽酶(glutamyl transpeptidase,GGT)、总胆红素(total bilirubin,TBiL)],匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)评分及不良反应发生率。结果 治疗后,观察组的AST[(33.45±8.32) U·L^(-1)]、ALT[(35.45±5.35) U·L^(-1)]、GGT[(31.12±5.15) U·L^(-1)]、TBiL[(6.44±2.53)μmol·L^(-1)]均低于对照组,组间比较差异均有统计学意义(P<0.05);治疗后,观察组的PSQI评分优于对照组(P<0.05);观察组的不良反应发生率(8.33%)低于对照组(26.67%),P<0.05。结论 五灵胶囊可有效防治由精神类药物造成的肝损伤,且有助于改善患者的情志抑郁、焦虑和失眠的症状,患者的生活质量明显改善,且安全性较好。

Objective To explore the effect of Wuling Capsules on preventing and treating liver injury caused by psychotropic drugs and its impact on patients’sleep quality.Methods From January 2021 to December 2023,240 patients with depression caused by psychotropic drugs in our hospital were enrolled and divided into 2 groups with 120 cases in each according to random number table method.After 12 weeks of treatment,the main liver function indicators of the 2 groups were compared,including alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutamyl transpeptidase(GGT),total bilirubin(TBiL),Pittsburgh sleep quality index(PSQI)score,and the incidence of adverse reactions.Results There was no difference in liver function indexes between the 2 groups before treatment(P>0.05).After treatment,the levels of AST[(33.45±8.32)U·L^(-1)],ALT[(35.45±5.35)U·L^(-1)],GGT[(31.12±5.15)U·L^(-1)],and TBiL[(6.44±2.53)μmol·L^(-1)]in the observation group were lower than those in the control group,with significant differences between the 2 groups(P<0.05).The PSQI score of the observation group was better than that of the control group after treatment,and the difference between the 2 groups was significant(P<0.05).The incidence of adverse reactions in the observation group was 8.33%lower than that in the control group(26.67%),and the difference between groups was significant(P<0.05).Conclusion Wuling Capsules can effectively prevent and treat liver damage caused by psychotropic drugs,and help to alleviate patients’symptoms of emotional depression,anxiety,and insomnia.The quality of life for patients is significantly enhanced,and the safety profile is favorable.