氨溴索雾化吸入联合静脉滴注治疗新生儿吸入性肺炎的疗效

Efficacy of ambroxol aerosol inhalation combined with intravenous infusion in the treatment of neonatal aspiration pneumonia

目的 探讨氨溴索静脉滴注联合雾化吸入治疗新生儿吸入性肺炎的临床疗效,并观察对肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、胰岛素样生长因子1(insulin-like growth factor,IGF-1)水平的影响。方法 选取收治的吸入性肺炎新生患儿80例,按随机数字表法分为对照组和观察组,每组40例。对照组常规静脉滴注盐酸氨溴索,观察组在对照组用药基础上联合应用盐酸氨溴索雾化吸入治疗,2组均治疗7 d,观察治疗疗效、症状消失时间、炎性反应、氧化应激反应和药物不良反应的发生情况。结果治疗后,观察组的临床有效率明显高于对照组(P<0.05);观察组患儿发热、咳嗽、肺部湿啰音和气喘症状消失时间均明显短于对照组(P<0.05);观察组TNF-α、白细胞介素-6(interleukin-6,IL-6)水平明显低于对照组(P<0.05),IGF-1水平明显高于对照组(P<0.05);观察组超氧化物歧化酶水平明显高于对照组(P<0.05),丙二醛水平明显低于对照组(P<0.05);2组患儿不良反应发生率比较差异无统计学意义(P>0.05)。结论 采用氨溴索静脉滴注联合雾化吸入治疗新生儿吸入性肺炎疗效确切,能显著改善患儿的临床症状,降低炎性因子和氧化应激指标水平,且具有一定的安全性。

Objective To investigate the clinical efficacy of ambroxol intravenous drip combined with atomization inhalation in the treatment of neonatal aspiration pneumonia,and to observe the effects on the levels of tumor necrosis factor-α(TNF-α)and insulin-like growth factor(IGF-1).Methods A total of 80 newborn children with aspiration pneumonia were selected and divided into observation group and control group according to random number table method,40 cases in each group.The control group was treated with conventional intravenous infusion of ambroxol hydrochloride,while the observation group was treated with atomization inhalation of ambroxol hydrochloride.The both groups were treated for 7 days.The curative effect,symptom disappear time,inflammatory reaction,oxidative stress reaction and adverse drug reaction were observed.Results After treatment,the clinical effective rate of observation group was significantly higher than that of control group(P<0.05).The time fever disappearance,cough,pulmonary rales and asthma in observation group was significantly shorter than that in control group(P<0.05).The levels of TNF-αand interleukin-6(IL-6)in observation group were significantly lower than those in control group(P<0.05),and the level of IGF-1 was significantly higher than that in control group(P<0.05).The level of superoxide dismutase(SOD)in observation group was significantly higher than that in control group(P<0.05),and the level of malondialdehyde(MDA)was significantly lower than that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion Ambroxol intravenous drip combined with atomization inhalation is effective in the treatment of neonatal aspiration pneumonia,which can significantly improve the clinical symptoms of the children,reduce the levels of inflammatory factors and oxidative stress indicators,and has a certain safety.