口腔扁平苔藓患者Hp感染状况分析及其与免疫功能的关系

Hp Infection Status in Patients with Oral Lichen Planus and Its Relationship with Immune Function

目的分析口腔扁平苔藓(OLP)患者幽门螺杆菌(Hp)感染状况及其与免疫功能相关性。方法回顾性选取2023年1—12月郑州大学第一附属医院收治的215例OLP患者作为OLP组,选取同期182例健康体检正常志愿者作为健康组。比较健康组、OLP组Hp感染情况,根据Hp检验结果将OLP组分为OLP阳性组和OLP阴性组,比较OLP阳性组和OLP阴性组各项免疫指标水平,分析免疫指标与OLP阳性相关性。结果健康组Hp感染率比OLP组更低;OLP阳性组总T淋巴细胞(T)+B淋巴细胞(B)+自然杀伤细胞(NK)、诱导T淋巴细胞(CD4^(+))、免疫球蛋白G(IgG)、补体C3(C3)、补体C4(C4)水平低于OLP阴性组,B淋巴细胞表面抗原(CD19^(+))、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)水平高于OLP阴性组;相关性分析可知,总T+B+NK、CD4^(+)、IgG、C3、C4与OLP阳性呈负相关关系(r=-0.961,-0.754,-0.501,-0.145,-0.669,P<0.05),CD19^(+)、IgA、IgM与OLP阳性呈正相关关系(r=0.443,0.475,0.349,P<0.05)。结论OLP患者有较高Hp感染率,且感染Hp的患者免疫功能较差,其中总T+B+NK、CD4^(+)、IgG、C3、C4与OLP患者Hp阳性呈负相关,CD19^(+)、IgA、IgM与OLP患者Hp阳性呈正相关,临床可将以上免疫功能指标作为评估OLP患者Hp阳性的指标。

Objective To analyse the status of Helicobacter pylori(Hp)infection in patients with oral lichen planus(OLP)and its correlation with immune function.Methods A total of 215 OLP patients admitted to the First Affiliated Hospital of Zhengzhou University from January to December 2023 were selected as the OLP group,and 182 healthy volunteers in the same period were selected as the healthy group.The Hp infection status was compared in the healthy group and OLP group,and the patients were divided the OLP group into OLP-positive and OLP-negative groups according to the results of the Hp test.The levels of various immune indexes in the OLP-positive group and OLP-negative group were compared,and the correlation between the immune indexes and OLP positivity was analyzed.Results The rate of Hp infection in the healthy group was lower than that in the OLP group.Total T-lymphocyte(T)+B-lymphocyte(B)+natural killer cell(NK),induced T lymphocyte(CD4^(+)),immunoglobulin G(IgG),complement 3(C3),complement 4(C4)levels were lower in the OLP-positive group than those in the OLP-negative group,and B-lymphocyte surface antigen(CD19^(+)),immunoglobulin A(IgA),immunoglobulin M(IgM)levels were higher than in the OLP-negative group.Correlation analysis showed that total T+B+NK,CD4^(+),IgG,C3,C4 were negatively correlated with OLP positivity(r=-0.961,-0.754,-0.501,-0.145,-0.669,P<0.05),and CD19^(+),IgA,IgM were positively correlated with OLP positivity(r=0.443,0.475,0.349,P<0.05).Conclusion OLP patients have a high rate of Hp infection,and patients infected with Hp have poor immune function,in which total T+B+NK,CD4^(+),IgG,C3,C4 are negatively correlated with Hp positivity in OLP patients,and CD19^(+),IgA,IgM are positively correlated with Hp positivity in OLP patients,and the clinic can use the above immune function indexes as an index to assess Hp positivity in OLP patients.