外周血CD4^(+)/CD8^(+)与支气管肺炎患儿临床预后的相关性

Correlation Between Peripheral Blood CD4^(+)/CD8^(+)and Clinical Prognosis in Children with Bronchopneumonia

目的探讨外周血CD4^(+)/CD8^(+)与支气管肺炎患儿临床预后的相关性。方法前瞻性纳入濮阳市第五人民医院2020年6月至2023年6月收治的120例支气管肺炎患儿,根据患儿治疗效果评估临床预后,将其分为预后良好组和预后不良组。所有患儿均于入院时检测T淋巴细胞亚群,计算CD4^(+)/CD8^(+)。采用点二列相关性检验外周血CD4^(+)/CD8^(+)与支气管肺炎患儿预后不良的关系,绘制受试者工作特征(ROC)曲线分析外周血CD4^(+)/CD8^(+)对支气管肺炎患儿预后不良的预测价值。结果本研究共纳入120例支气管肺炎患儿,其中23例预后不良,占比19.17%,纳入预后不良组,其余97例患儿纳入预后良好组。预后不良组患儿CD4^(+)、CD4^(+)/CD8^(+)均低于预后良好组,CD8^(+)高于预后良好组,差异有统计学意义(P<0.05)。经点二列相关性分析,CD4^(+)、CD4^(+)/CD8^(+)均与支气管肺炎患儿预后不良呈负相关关系(r<0,P<0.05),CD8^(+)与支气管肺炎患儿预后不良呈正相关关系(r>0,P<0.05)。绘制ROC曲线显示,CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)对支气管肺炎患儿预后不良均有一定预测价值(曲线下面积>0.70),且以CD4^(+)/CD8^(+)预测效能最佳。结论入院时外周血CD4^(+)/CD8^(+)与支气管肺炎患儿预后不良具有相关性,CD4^(+)/CD8^(+)越低,患儿预后不良风险越高,CD4^(+)/CD8^(+)可作为支气管肺炎临床预后的预测指标。

Objective To explore the correlation between peripheral blood CD4^(+)/CD8^(+)and clinical prognosis in children with bronchopneumonia.Methods A total of 120 children with bronchopneumonia admitted to the Fifth People’s Hospital of Puyang City from June 2020 to June 2023 were prospectively included.Clinical prognosis was evaluated based on the treatment effectiveness of the children,and they were divided into a good prognosis group and a poor prognosis group.All children were tested for T lymphocyte subpopulations and CD4^(+)/CD8^(+)were calculated at admission.The relationship between peripheral blood CD4^(+)/CD8^(+)and poor prognosis in children with bronchopneumonia was tested using point two column correlation,and the predictive value of peripheral blood CD4^(+)/CD8^(+)for poor prognosis in children with bronchopneumonia was analyzed by drawing a receiver operating characteristic(ROC)curve.Results A total of 120 children with bronchopneumonia were included in this study,of which 23 children had poor prognosis,accounting for 19.17%.They were included in the poor prognosis group,while the remaining 97 children were included in the good prognosis group.The CD4^(+)and CD4^(+)/CD8^(+)levels in the poor prognosis group were lower than those in the good prognosis group,and CD8^(+)level was higher than that in the good prognosis group,with a statistical significant difference(P<0.05).Through point two column correlation analysis,both CD4^(+)and CD4^(+)/CD8^(+)were negatively correlated with poor prognosis in children with bronchopneumonia(r<0,P<0.05),while CD8^(+)was positively correlated with poor prognosis in children with bronchopneumonia(r>0,P<0.05).The ROC curve showed that CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)had certain predictive value for poor prognosis in children with bronchial pneumonia(area under the curve>0.70),and CD4^(+)/CD8^(+)had the best predictive efficacy.Conclusion There is a correlation between peripheral blood CD4^(+)/CD8^(+)at admission and poor prognosis in children with bronchopneumonia.The lower CD4^(+)/CD8^(+),the higher the risk of poor prognosis in children.CD4^(+)/CD8^(+)can be used as a predictive indicator for clinical prognosis of bronchopneumonia.