血清VEGF表达对重度子痫前期患者胎盘早剥的预测价值

Predictive Value of Serum VEGF Expression in the Occurrence of Placental Abruption in Patients with Severe Preeclampsia

目的分析血清血管内皮生长因子(VEGF)表达与重度子痫前期患者胎盘早剥的关系,并探究其对患者胎盘早剥发生情况的预测价值。方法采用前瞻性研究,纳入2020年1月至2023年1月焦作市妇幼保健院产科收治的100例重度子痫前期患者,入院时检测患者VEGF表达,于孕28周时检查其胎盘早剥情况,统计胎盘早剥发生情况,分析VEGF表达与重度子痫前期患者胎盘早剥发生的关系;同时绘制受试者工作特征(ROC)曲线,分析血清VEGF表达对重度子痫前期患者胎盘早剥发生的预测价值。结果100例重度子痫前期患者中发生胎盘早剥17例,占比17.00%(17/100);未发生胎盘早剥83例,占比83.00%(83/100)。发生组血清VEGF水平高于未发生组(P<0.05);经点二列相关性分析,血清VEGF表达与重度子痫前期患者胎盘早剥发生呈正相关(r>0,P<0.05)。绘制ROC曲线,结果显示,血清VEGF表达预测重度子痫前期患者胎盘早剥发生的曲线下面积>0.7,具有一定的预测价值。结论血清VEGF表达与重度子痫前期患者胎盘早剥的发生情况有关,且可预测胎盘早剥发生风险。

Objective To analyze the relationship between serum vascular endothelial growth factor(VEGF)expression and placental abruption in severe preeclampsia patients,and to explore its predictive value for the occurrence of placental abruption in patients.Methods A prospective study was conducted on 100 patients with severe preeclampsia admitted to Department of Obstetrics of Maternal and Child Health Hospital of Jiaozuo from January 2020 to January 2023.The expression of VEGF was detected on admission,and the placental abruption was examined at 28 weeks of gestation,and the occurrence of placental abruption was counted.The relationship between VEGF expression and placental abruption in patients with severe preeclampsia was analyzed.At the same time,the receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum VEGF expression on the occurrence of placental abruption in severe preeclampsia patients.Results Among the 100 patients with severe preeclampsia,17 cases had placental abruption,accounting for 17.00%(17/100),83 cases did not occur placental abruptionr,accounting for 83.00%(83/100).The serum VEGF levels of patients in the occurrence group were higher than those in the non-occurrence group(P<0.05).Through point binary correlation analysis,the expression of serum VEGF was positively correlated with the occurrence of placental abruption in patients with severe preeclampsia(r>0,P<0.05).The ROC curve was plotted,and the results showed that the area under the curve of serum VEGF expression predicting the occurrence of placental abruption in severe preeclampsia patients was greater than 0.7,which had certain predictive value.Conclusion The expression of serum VEGF is related to the occurrence of placental abruption in patients with severe preeclampsia,and can predict the risk of placental abruption.