桂枝加龙骨牡蛎汤治疗失眠的研究进展

Research Progress of Guizhi plus Longgu Oyster Soup in Treating Insomnia

当前,失眠是影响人类生活质量及身体健康的重要疾病之一,患病率可达40%,中医治疗失眠历史悠久,以其独特的治疗优势越来越受到国内外临床及药物研究的重视,中药复方又具有多靶点,多途径,安全性高等优点,成为祖国医学治疗失眠的首要方法。桂枝加龙骨牡蛎汤出自“医圣”张仲景之手,有调和阴阳,潜镇摄纳的功效,《金匮要略》中原方用于治疗久病虚劳、阴阳两虚、阴阳不交所致的遗精、遗尿、梦交等病证。通过查阅文献发现,不同因素引起阴阳不和导致的失眠,使用该方治疗亦可取得良好的临床疗效。本文章通过查阅近年来桂枝加龙骨牡蛎汤治疗失眠的相关文献,就其应用及现代药理学机制进行综述,为该方进一步研究提供参考。

At present,insomnia is one of the important diseases affecting human life quality and physical health,the prevalence rate can reach 40%,traditional Chinese medicine treatment of insomnia has a long history,with its unique therapeutic advantages more and more attention at home and abroad clinical and drug research,Chinese medicine compound has multiple targets,multiple approaches,high safety advantages,become the primary method of Chinese medicine treatment of insomnia.Guizhi plus Longgu Oyster soup from the"medical sage"Zhang Zhongjing hands,has the effect of harmonizing Yin and Yang,latent control of absorption.The Central Plains Prescription in Synopsis of the Golden Chamber is used to treat such diseases as spermatorhea,enuresis,and dream intercourse caused by chronic illness,deficiency of both yin and yang,and lack of yin and yang.Through literature review,it is found that different factors cause insomnia caused by Yin and Yang disharmony,and the use of this prescription can also obtain good clinical effect.In this paper,the application and modern pharmacological mechanism of the decoction were reviewed by referring to the literatures on the treatment of insomnia in recent years,so as to provide reference for further study of the decoction.