细菌纤维素合成酶亚基多样性和纤维结构形成研究进展

Research progress in bacterial cellulose synthase subunit diversity and fiber structure formation

细菌纤维素(bacterial cellulose,BC)是由细菌代谢所产生的葡萄糖聚合物。细菌纤维素合成酶(bacterial cellulose synthase,BCS)是催化BC形成的关键酶。BCS不同种类亚基之间的协同性能够确保BC的胞内形成及胞外分泌。本文主要总结了已报道的BC合成菌株的种类,分析了不同菌株中BCS的区别,并综述了BC合成机制、BCS中亚基之间的相互作用及菌株内自身结构特征对高度有序纤维结构的形成的影响等方面的研究进展。全面了解BC的合成与分泌机制,可为合成生物学技术优化BC合成提供更多策略。

Bacterial cellulose(BC)is the glucose polymer produced by bacterial metabolism.The bacterial cellulose synthase(BCS)is the key enzyme for catalyzing the formation of BC.The cooperation between different submits of BCS is necessary for the intracellular formation and extracellular secretion of BC.This review summarized the BC-producing strains and the differences of BCS among different strains.Furthermore,we detailed the BC synthesis mechanism,the interactions between BCS subunits,and the relationship between the structural characteristics of strains and the formation of highly ordered fiber structures.A comprehensive insight into the mechanism of BC synthesis and secretion will supply more strategies for optimizing the BC synthesis via methods of synthetic biology.