甘草泻心汤联合复方嗜酸乳杆菌对儿童轮状病毒性肠炎的疗效及免疫功能的影响

Therapeutic effect Impacts of Gancao Xiexin decoction combined with compound Lactobacillus acidophilus on therapeutic effect andimmune function in children with rotavirus enteritis

目的 分析甘草泻心汤联合复方嗜酸乳杆菌治疗儿童轮状病毒性肠炎的疗效以及对儿童免疫功能的影响。方法 选择2023年1月-2023年12月在本院接受治疗的82例湿热证轮状病毒性肠炎儿童,根据随机数字表+信封袋法将其分为联合组(41例)和单一组(41例);联合组在对症治疗的基础上给予甘草泻心汤联合复方嗜酸乳杆菌治疗,单一组在对症治疗的基础上给予复方嗜酸乳杆菌治疗;比较两组轮状病毒性肠炎症状缓解时间、临床疗效、免疫功能以及炎症因子水平。结果 联合组腹泻完全停止时间、脱水纠正时间、轮状病毒抗原转阴时间以及恢复正常体温时间均短于单一组(P<0.05)。联合组临床总有效率(92.68%)显著高于单一组(75.61%)(P<0.05)。治疗后两组CD4^(+)、IgM、IgA水平及CD4^(+)/CD8^(+)值显著上升,CD8^(+)水平显著下降(P<0.05);与单一组相比,联合组治疗后CD4^(+)、IgM、IgA水平及CD4^(+)/CD8^(+)值显著上升,CD8^(+)水平显著下降(P<0.05)。治疗后两组IL-6水平显著下降,联合组hs-CRP水平显著下降(P<0.05);与单一组相比,联合组治疗后IL-6水平显著下降(P<0.05),两组治疗后hs-CRP、PCT水平无差异(P>0.05)。治疗后两组VIP、MOT、GAS水平显著下降(P<0.05);与单一组相比,联合组治疗后VIP、MOT、GAS水平显著下降(P<0.05)。治疗后两组双歧杆菌、嗜酸乳酸菌水平上升、大肠埃希菌水平下降(P<0.05);与单一组相比,联合组治疗后双歧杆菌、嗜酸乳酸菌水平上升、大肠埃希菌水平下降(P<0.05)。结论 甘草泻心汤联合复方嗜酸乳杆菌治疗儿童轮状病毒性肠炎能够有效缓解患儿的临床症状,抑制炎症因子与胃肠激素水平,提高免疫功能,调节肠道菌群。

Objective To analyze the therapeutic effect of Gancao Xiexin decoction combined with compound Lactobacillus acidophilus on children with rotavirus enteritis and its impact on their immune function.MethodsFrom January 2023 to December 2023,82 children with rotavirus enteritis of damp heat syndrome who received treatment in our hospital were collected.They were randomly grouped into a combined group(41 cases)and a single group(41 cases)using a random number table and envelope bag method;on the basis of symptomatic treatment,the combined group was given Gancao Xiexin decoction combined with compound Lactobacillus acidophilus,while the single group was given compound Lactobacillus acidophilus treatment on the basis of symptomatic treatment.The time of symptom relief,clinical efficacy,immune function,and levels of inflammatory factors were compared.Results The time for complete cessation of diarrhea,dehydration correction time,negative conversion time of rotavirus antigen,and time for body temperature to return to normal in the combined group were all shorter than those in the single group(P<0.05).The total clinical effective rate of the combined group(92.68%)was obviously higher than that of the single group(75.61%)(P<0.05).After treatment,the levels of CD4^(+),IgM,IgA,and CD4^(+)/CD8+value obviously increased in both groups,while the level of CD8+obviously decreased(P<0.05);compared with the single group,the combined group showed a obvious increase in CD4^(+),IgM,IgA levels and CD4^(+)/CD8^(+)value after treatment,and a obvious decrease in CD8+level(P<0.05).After treatment,the level of IL-6 in both groups obviously decreased and hs-CRP level in the combined group obviously decreased(P<0.05);compared with the single group,the combined group showed a obvious decrease in IL-6 level(P<0.05),and the levels of hs-CRP and PCT were not different after treatment(P>0.05).After treatment,the levels of VIP,MOT,and GAS in both groups obviously decreased(P<0.05);compared with the single group,the combined group showed a great decrease in VIP,MOT,and GAS levels after treatment(P<0.05).After treatment,the levels of Bifidobacterium and Lactobacillus acidophilus increased and the level of Escherichia coli decreased in both groups(P<0.05);compared with the single group,the combined group showed an increase in levels of Bifidobacterium and Lactobacillus acidophilus,and a decrease in level of Escherichia coli after treatment(P<0.05).Conclusion The combination of Gancao Xiexin decoctionand compound Lactobacillus acidophilus can effectively alleviate the clinical symptoms of children with rotavirus enteritis,inhibit the levels of inflammatory factors and gastrointestinal hormones,improve immune function,and regulate intestinal flora.