结核肉芽肿研究模型综述:类器官技术的潜力与挑战

A review of research models for tuberculous granuloma:Potential and challenges of organoid techniques

结核病是一种慢性传染病,其治疗周期较长,且容易产生耐药性。这与结核杆菌诱导机体生成结核肉芽肿之间存在密切关系。为了系统地研究结核肉芽肿,出现了许多构建生物模型的方法。在本文献综述中分析了结核肉芽肿的形成机制,比较了现有的生物模型构建方法,并探讨了类器官技术在构建新型结核肉芽肿体外模型的潜力与挑战,旨在为研发新型抗结核药物及优化治疗方案提供一个全新切入点。

Tuberculosis is a chronic infectious disease,which has a lengthy treatment cycle and a tendency to develop drug resistance.Thisissue is closely related to the formation of tuberculous granuloma induced by Mycobacterium tuberculosis.To systematically study tuberculous granulomas,various methods for constructing biological models have been developed.In this review,we analyzed the mechanism of tuberculousgranuloma formation,compared and contrasted existing methods for constructing biological models,and assessed the potential and challenges of using organoid technology to create innovative in vitro models of tuberculous granulomas.The goal is to provide a fresh perspective for the development of innovative anti-tuberculosis drugsand the optimization of treatment strategies.