丁酸钠治疗非酒精性脂肪性肝病的作用与机制研究进展

Research progress of effect and mechanism of sodium butyrate in the treatment of non-alcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)是一种与代谢综合征紧密相关的全球性肝脏疾病。丁酸钠为一种由肠道微生物产生的短链脂肪酸,在NAFLD治疗中显示出潜在的效果。丁酸钠可通过调控基因表达、促进脂肪酸β-氧化和抑制脂质合成来改善脂质代谢。同时,其抗炎特性有助于减轻肝脏炎症,而维护肠道屏障和微生物平衡对防止NAFLD的发展至关重要。尽管丁酸钠治疗NAFLD的前景广阔,但现有研究主要集中在动物模型上,需更多临床试验来验证其在人类NAFLD治疗中作用。本综述探讨丁酸钠的来源、功能,以及对NAFLD基因表达、脂质代谢的调控和炎症反应、肠道屏障功能的影响,并评估了其在临床应用中的前景,以期为未来的研究提供方向。

Non-alcoholic fatty liver disease(NAFLD)is a global liver disease closely associated with metabolic syndrome.Sodium Butyrate,a short-chain fatty acid produced by gut microbes,has shown potential in the treatment of NAFLD.Sodium Butyrate improves lipid metabolism by regulating gene expression,promoting fatty acidβ-oxidation,and inhibiting lipid synthesis.Additionally,its anti-inflammatory properties help to alleviate liver inflammation,and maintaining intestinal barrier and microbial balance is crucial in preventing the development of NAFLD.Although Sodium Butyrate holds great promise in the treatment of NAFLD,existing studies have mainly focused on animal models,and more clinical trials are needed to verify its role in the treatment of NAFLD in humans.This review discusses the source and function of Sodium Butyrate,as well as its effects on NAFLD gene expression,lipid metabolism regulation,inflammatory response,and intestinal barrier function,and evaluates its prospects for clinical application,with a view to providing directions for future research.