原子吸收分光光度法测定注射用头孢唑林钠中钠含量

Analysis of Sodium Content in Cefazolin Sodium for Injection

采用原子吸收分光光度法测定注射用头孢唑林钠中钠的含量。光源为钠空心阴极灯,空气-乙炔火焰原子化器,波长330.2nm。该方法的检测限为0.09%,定量限为0.31%,系统精密度RSD为0.68%(n=6),重复性RSD为0.62%,中间精密度RSD为1.49%,线性范围为0.2003~0.4007mg/m L(r=0.999),平均回收率为100.8%(RSD为0.91%)。该方法专属性、精密度、线性、耐用性等参数符合要求,可用于测定注射用头孢唑林钠中钠的含量,准确度和灵敏度高。

The research is dedicated to determining the content of sodium in cefazolin sodium for injection by atomic absorption spectrophotometry.Atomic absorption spectrophotometry was used,the light source was a sodium hollow cathode lamp,the atomizer was an air-acetylene flame atomizer,and the wavelength was 330.2 nm.The detection limit of this method was 0.09%,the quantitative limit was 0.31%,the system precision RSD was 0.68%(n=6),the repeatable RSD was 0.62%,the intermediate precision RSD was 1.49%,and the linear range was 0.2003~0.4007 mg/mL(r=0.999).The average recovery rate was 100.8%(RSD was 0.91%).The specificity,precision,linearity and durability of this method meet relevant requirements.This method can be used to determine the content of sodium in cefazolin sodium for injection with high accuracy and sensitivity.