草乌甲素片联合普瑞巴林胶囊治疗带状疱疹后遗神经痛疗效

Therapeutic effect of bulleyaconitine tablets combined with pregabalin capsule on postherpetic neuralgia

目的:探讨草乌甲素片联合普瑞巴林胶囊治疗带状疱疹后遗神经痛的疗效。方法:选取2017年1月至2023年10月期间本院门诊接收的115例带状疱疹后遗神经痛患者,随机分为对照组(n=57)和观察组(n=58)。对照组采用普瑞巴林胶囊口服治疗,起始剂量为75mg·次-1,2次·d-1,治疗1w内,根据疗效及耐受性增加至150mg·次-1,2次·d-1;观察组在对照组基础上联合草乌甲素片口服治疗,1片·次-1,2次·d-1,2次服药间隔时间≥6 h,2组均治疗4 w。观察两组疗效,并于治疗前、治疗结束次日时采用匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评估睡眠质量,采用酶联免疫吸附法测定炎症因子-C反应蛋白(Creactiveprotein,CRP)水平,统计并比较治疗期间不良反应发生情况,并通过微信或者电话的方式随访3 m,统计随访期间复发率。结果:治疗后,观察组治疗总有效率比对照组高(P<0.05)。治疗后,两组的PSQI评分均比治疗前显著降低,且观察组治疗后的PSQI评分低于对照组(P<0.05)。治疗结束后,两组的CRP水平均显著低于治疗前,且观察组的CRP水平显著低于对照组(P<0.05)。治疗期间,两组的不良反应发生率比较无显著差异(P>0.05)。随访3m期间,观察组复发率低于对照组(P<0.05)。结论:草乌甲素片联合普瑞巴林胶囊治疗带状疱疹后遗神经痛,缓解疼痛效果更佳,可提高睡眠质量,缓解炎症,且复发率低,安全性较高。

Objective:To investigate the curative effect of bulleyaconitine tablets combined with pregabalin capsules in treating postherpetic neuralgia.Methods:A total of 115 patients with postherpetic neuralgia who were admitted to our hospital from January 2017 to October 2023 were randomly divided into a control group(n=57)and an observation group(n=58).The control group was treated with oral pregabalin capsules,starting at a dose of 75 mg•time-1,2 times•day-1.Within 1 week of treatment,the dose was increased to 150 mg•time-1,2 times•day-1 based on efficacy and tolerability.The observation group was treated based on the control group combined with bulleyaconitine tablets,and both groups were treated for 4 weeks.The interval between the two administrations was≥6 hours.Both groups were treated for 4 weeks.The efficacy of the two groups was observed,and the Pittsburgh sleep quality index(PSQI)was used to assess sleep quality before and on the second day after treatment.The C-reactive protein(CRP)level was measured by enzyme-linked immunosorbent assay,and the incidence of adverse reactions during treatment was statistically compared.Follow-up visits were conducted via WeChat or telephone for three months,and the recurrence rate during follow-up was statistically analyzed.Results:After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the PSQI scores of both groups were significantly lower than those before treatment,and the PSQI score of the observation group after treatment was lower than that of the control group(P<0.05).After the end of treatment,the CRP levels of both groups were significantly lower than those before treatment,and the CRP level of the observation group was significantly lower than that of the control group(P<0.05).During the treatment period,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).During the 3-month follow-up period,the recurrence rate of the observation group was lower than that of the control group(P<0.05).Conclusion:The combination of bulleyaconitine tablets and pregabalin capsules has a better pain relief effect in treating postherpetic neuralgia.It can improve sleep quality,alleviate inflammation,and has a low recurrence rate and high safety.