非布司他辅助塞来昔布治疗对高尿酸血症痛风患者疗效、疼痛以及炎性因子的影响

Effect of Febuxostat-assisted celecoxib therapy on the efficacy,pain and inflammatory factors of hyperuricemic gout patients

目的:探讨高尿酸血症痛风患者应用非布司他辅助塞来昔布治疗的临床疗效及对疼痛以及炎性因子的影响。方法:选取2021年3月至2023年3月期间本院收治的78例高尿酸血症痛风患者为研究对象。随机将患者分为对照组和研究组,每组各39例。对照组接受塞来昔布胶囊治疗;研究组接受非布司他片辅助塞来昔布胶囊治疗。治疗7 d后分析比较两组的临床疗效,疼痛程度、炎性因子水平以及不良反应。结果:较之对照组,研究组的临床治疗总有效率显著提高(P<0.05)。治疗后,两组的视觉模拟评分法(Visual analogue scale,VAS)评分均比治疗前显著降低,且研究组的VAS评分显著低于对照组(P<0.05),治疗后,两组的肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、细胞介素1β(Interleukin-1β,IL-1β)、C反应蛋白(C-reactive protein,CRP)、红细胞沉降率(Erythrocyte sedimentation Rate,ESR)水平均比治疗前明显降低,且研究组的TNF-α、IL-1β、CRP、ESR水平均显著低于对照组(P<0.05)。结论:非布司他辅助塞来昔布治疗高尿酸血症痛风,能提高临床疗效,缓解患者疼痛,改善其炎性因子水平,且安全性较高。

Objective:To investigate the clinical effect of febuxostat assisted celecoxib in the treatment of hyperuricemia gout and its effect on pain and inflammatory factors.Methods:78 patients with hyperuricemia gout admitted to our hospital from March 2021 to March 2023 were selected as the study objects.The patients were randomly divided into control group and study group,39 cases in each group.The control group was treated with celecoxib capsule;the study group was treated with febuxostat tablets and celecoxib capsules.After 7 days of treatment,the clinical efficacy,pain degree,inflammatory factor level and adverse reactions of the two groups were analyzed and compared.Results:Compared with the control group,the total effective rate of the study group was significantly increased(P<0.05).After treatment,the visual analogue scale(VAS)score of both groups was significantly lower than that before treatment,and the VAS score of the study group was significantly lower than that of the control group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),C-reactive protein(CRP)and erythrocyte sedimentation Rate(ESR)in both groups were significantly lower than those of the treatment.The levels of TNF-α,IL-1β,CRP and ESR in the study group were significantly lower than those in the control group(P<0.05).Conclusion:Febuxostat assisted celecoxib in the treatment of hyperuricemia gout,which can improve the clinical effect,relieve pain and improve the level of inflammatory factors,with high safety.