D-D、AT-Ⅲ与乙型肝炎患者严重程度的相关性分析

Correlation between D-D,AT-Ⅲ and severity of hepatitis B virus

目的:探究血浆D-二聚体(D-dimer,D-D)、抗凝血酶Ⅲ(Antithrombin III,AT-Ⅲ)与乙型肝炎患者严重程度的相关性。方法:选取2020年12月~2023年12月期间我院收治的60例乙型肝炎患者的临床及随访资料进行研究。根据病情严重程度将患者分为轻度组(n=22)、中度组(n=26)、重度组(n=12)。比较三组患者D-D、AT-Ⅲ水平的差异。采用Spearman相关系数分析D-D、AT-Ⅲ与乙型肝炎患者严重程度的相关性。结果:重度组患者的D-D水平明显高于轻度组、中度组;重度组患者的AT-Ⅲ水平低于轻度组、中度组;中度组患者的D-D水平高于轻度组,AT-Ⅲ水平低于轻度组(P<0.05)。Spearman相关分析结果显示,患者血浆D-D与乙型肝炎患者病情的严重程度呈正相关(r=0.721,P<0.05);AT-Ⅲ水平与乙型肝炎患者病情严重程度呈负相关(r=-0.685,P<0.05)。结论:D-D和AT-Ⅲ水平与乙型肝炎患者病情的严重程度存在明显的相关性。D-D水平升高和AT-Ⅲ水平降低可能是乙型肝炎患者病情加重的重要标志。

Objective:To explore the correlation between plasma D-dimer(D-D),antithrombin Ⅲ(AT-Ⅲ)and the severity of hepatitis B virus(HBV).Methods:The clinical and follow-up data were collected from 60 patients with HBV in the hospital between December 2020 and December 2023.According to disease severity,patients were divided into mild group(n=22),moderate group(n=26)and severe group(n=12).The differences in D-D and AT-Ⅲ levels among the three groups were compared.Correlation between D-D,AT-Ⅲ and HBV severity was analyzed by Spearman correlation coefficient.Results:D-D level was gradually decreased,while AT-Ⅲ level was gradually increased in severe group,moderate group and mild group(P<0.05).The results of Spearman correlation analysis showed that level of plasma D-D was positively correlated with the severity of HBV(r=0.721,P<0.05),while AT-Ⅲlevel was negatively correlated with it(r=-0.685,P<0.05).Conclusion:The level of D-D and AT-Ⅲ are significantly correlated with HBV severity.D-D increase and AT-Ⅲdecrease may be important markers of disease aggravation in HBV patients.