非人灵长类和非灵长类糖尿病动物模型构建方法的研究进展

Research Progress on the construction methods of non-human primate and non-primate diabetes animal models

关于糖尿病动物模型的研究,国内外均主要集中于大鼠、小鼠、兔,其方法涉及自发性动物模型、转基因、高脂高糖饲料诱导和化学诱导等。虽然兔和啮齿动物模型对糖尿病机制的研究做出了重要贡献,但其生理结构和遗传背景与人类仍有较大区别,无法很好的模拟人类糖尿病发生发展过程。非人灵长类动物(NHP)与人类具有重要的代谢相似性,这使其成为研究糖尿病机制研究和临床前试验的理想模型。本综述简述了目前主要的NHP和非灵长类糖尿病模型构建方法和研究进展。

The research on animal models of diabetes at home and abroad is mainly focused on rabbits,rats,and mice,and its methods involve spontaneous animal models,transgenic,high-fat,and high-sugar diet induction,and chemical induction.Although rabbit and rodent models have made important contributions to the study of the mechanism of diabetes,their physiological structure and genetic background are still quite different from those of humans,which cannot well simulate the occurrence and development of human diabetes.Nonhuman primates(NHPs)have important metabolic similarities with humans,which makes them an ideal model for studying the mechanism of diabetes and preclinical trials.This review briefly describes the methods and research progress of the current major NHP diabetes model construction.