食用燕窝和唾液酸对抗氧化影响的定性研究

Impact of Edible Bird's Nest and Sialic Acid on Antioxidant Ability: A QualitativeEvidence-based Study

背景:燕窝的食用历史悠久,具有食药两用的特征,被人们尊崇为珍馐佳肴和滋补圣品。尽管有研究表明燕窝或其有效成分唾液酸具有抗氧化的功效,目前还缺乏系统分析燕窝的抗氧化作用的相关研究。目的:系统评价燕窝和唾液酸对抗氧化的作用及其潜在机制。方法:采用关键词“燕窝”或“唾液酸”以及“抗氧化”,针对2012—2022年间相关学术文献进行全面检索,包括PubMed、Embase、中国知网、万方和中国生物医学文献数据库。严格按照纳排标准筛选所检索的相关文章。文献风险评估采用SYRCLE动物实验风险评估工具。结果:6项动物模型实验研究被最终纳入。综述结果表明:燕窝和唾液酸有促进动物机体抗氧化能力的潜在功效,并存在剂量效应。燕窝和唾液酸可能通过增加抗氧化物质来提升抗氧化能力,同时减少炎症和氧化应激水平。结论:动物模型实验结果表明燕窝和唾液酸有助于提高抗氧化能力,并且效果与摄入量成正比。然而,由于目前缺乏相关的临床实验数据,因此尚无法确定燕窝对人体抗氧能力的影响。

Background:The consumption of Edible Bird’s Nests(EBN)has a long history.It has been regarded as a high-grade health food and tonic due to its characteristics of high nutritional values and medicinal properties.Although some studies stated that EBN or its active ingredients,sialic acid,has antioxidant effects,there is a lack of studies that systematically investigate the antioxidant effects of EBN.Objective:To systematically evaluate the efficacy of EBN on antioxidant capacity.Method:Relevant studies published between September 1,2012,and September 1,2022,were searched and selected using‘bird nest OR sialic acid’and‘antioxidant’as search terms across China National Knowledge Infrastructure(CNKI),Wanfang Database,China Biology Medicine disc(CBMdisc),PubMed and Embase.The selection of relevant studies was guided by predefined inclusion and exclusion criteria.The bias risks of selected studies were based on the SYRCLE's animal research bias risk tool.Result:Six animal model experiments were finally included in total.Results suggested that EBN and sialic acid has a potential role in up-regulating antioxidant activities.EBN or sialic acid may enhance antioxidant capacity by increasing the levels of antioxidants,while simultaneously reducing the occurrence of inflammation and oxidative stress.However,this review did not conduct a meta-analysis.Conclusion:Animal studies indicate a dose-dependent improvement in antioxidant capacity with EBN and sialic acid,but their effects on humans remain uncertain due to the absence of clinical trials.