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A lethal mice model of recombinant vesicular stomatitis viruses for EBOV-targeting prophylactic vaccines evaluation

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摘要 Dear editor,Ebola virus(EBOV)is a member of the genus Orthoebolavirus within the family of Filoviridae.It's the causative agent of Ebola virus disease(EVD),characterized by general malaise,severe gastrointestinal illness,febrile,coagulopathy,multi-organs dysfunction,and high mortality(up to 90%)in humans and nonhuman primates(NHPs)(Jacob et al.,2020).Since its discovery in 1976,EBOV has grabbed the global concerns,especially after the West African epidemic from 2014 to 2016,which resulted in 30,000 cases and over 11,000 deaths(Feldmann et al.,2020;Jacob et al.,2020).From 2018 to 2022,there have been thousands of infections primarily in the Democratic Republic of the Congo(DRC),resulting in over 2000 deaths.This highlights the importance of continued attention and ongoing surveillance(www.who.int/emergenci es/disease-outbreak-news).
出处 《Virologica Sinica》 SCIE CAS CSCD 2024年第3期516-519,共4页 中国病毒学(英文版)
关键词 ORGANS MORTALITY EDITOR
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