外泌体在多发性骨髓瘤发病机制中的研究进展

Research Advances of Exosomes in Pathogenesis of Multiple Myel loma——Review

关于外泌体参与多发性骨髓瘤发病机制及预后判定的研究已取得了一定的进展,但具体机制尚未阐明。近年来,国内外研究者进行了更深入的研究。本文主要阐述外泌体在骨髓微环境的改变、免疫抑制、骨髓瘤骨病的产生及骨髓瘤耐药等病理生理过程中的作用,为进一步探讨外泌体作为多发性骨髓瘤潜在生物标志物的临床研究提供新参考。

Research on the participation of exosomes in pathogenesis and prognosis of multiple myeloma(MM)has made encouraging progress.However,the specific mechanism has not yet been clarified.Recently,domestic and foreign researchers have pressed forward on deeper study on exosomes.This article mainly summarizes the role of exosomes in the pathophysiological processes,such as bone marrow microenvironment changes,immunosuppression,myeloma bone disease generation and myeloma drug resistance,so as to provide new reference for further clinical research of exosomes as potential biomarkers for MM.