CT血管成像在评估冠状动脉斑块周围脂肪体积与冠状动脉血流动力学异常关系中的价值

Value of CTA in assessing the relationship between the fat volume around coronary artery plaques and the abnormal coronary artery hemodynamics

目的:探索冠状动脉CT血管成像(CCTA)在评估冠状动脉斑块周围脂肪体积与冠状动脉血流动力学异常关系中的价值。方法:回顾性选取2022年6月至2023年9月沧州市人民医院收治的218例住院患者资料,将其中108例非冠心病患者纳入对照组,110例冠心病患者纳入观察组,所有患者均进行CCTA检查,比较两组心周脂肪体积、血流储备分数CT成像(FFRCT)值,经受试者工作特征(ROC)曲线分析,心周脂肪体积、FFRCT值预测冠状动脉斑块效能,经Pearson法分析心周脂肪体积与FFRCT的相关性。结果:观察组心周脂肪体积(168.70±38.16)cm^(3),高于对照组的(98.75±21.19)cm^(3),FFRCT值(0.78±0.11)低于对照组的(0.89±0.10),差异有统计学意义(t=16.688、8.041,P<0.05)。观察组有斑块患者89例,无斑块患者21例,有斑块患者心周脂肪体积(176.63±34.15)cm^(3),高于无斑块患者的(133.52±36.85)cm^(3),FFRCT值为0.76±0.10,低于无斑块患者的0.85±0.11,差异有统计学意义(t=4.945、3.815,P<0.05)。经Pearson法分析,心周脂肪体积与FFRCT呈负相关性。经Spearman法分析,冠心病患者有无斑块与心周脂肪体积呈正相关性,与FFRCT呈负相关性。经ROC曲线分析,心周脂肪体积、FFRCT及联合预测冠心病患者斑块的ROC曲线下面积(AUC)分别为0.777、0.726和0.930。结论:CCTA测量的血流动力学、心周脂肪体积可预测冠状动脉斑块情况,且冠状动脉血流动力学与冠状动脉斑块周围脂肪体积存在一定关系。

Objective:To explore the value of coronary computed tomography angiography(CCTA)in assessing the relationship between the fat volume around coronary plaque and the abnormal coronary hemodynamics.Methods:A total of 218 hospitalized patients admitted to Cangzhou People's Hospital from June 2022 to September 2023 were selected.In these patients,108 patients without coronary heart disease(CHD)were included in the control group,and 110 CHD patients were included in the observation group.All patients underwent CCTA examination to compare the CT imaging values(FFRCT)of the fat volume around heart and blood flow reserve fraction between the two groups.Receiver operating characteristic(ROC)curve was performed to analyze the efficacy of the fat volume around heart and FFRCT values in predicting coronary artery plaques.Additionally,Pearson's method was used to analyze the correlation between fat volume around heart and FFRCT.Results:The fat volume around heart in the observation group was(168.70±38.16)cm^(3),which was significantly higher than(98.75±21.19)cm^(3) in the control group,and the FFRCT value(0.78±0.11)of the observation group was lower than(0.89±0.10)in the control group,with statistically significant differences(t=16.688,8.041,P<0.05),respectively.In the observation group,89 patients occurred plaque,and 21 patients did not occur plaque.In the observation group,the fat volume around heart in patients with plaques was(176.63±34.15)cm^(3),which was significantly higher than(133.52±36.85)cm^(3) in patients without plaques,and the FFRCT value in patients with plaques was(0.76±0.10),which was significantly lower than(0.85±0.11)in patients without plaques,with statistically significant differences(t=4.945,3.815,P<0.05),respectively.According to Pearson's analysis,there was a negative correlation between the fat volume around heart and FFRCT value.According to Spearman's analysis,with or without plaques appeared positive correlation with the fat volume around heart in CHD patients,and they appeared negative correlation with FFRct value.According to ROC curve analysis,the area under curve(AUC)values of fat volume around heart,FFRCT,and the combination of them were respectively 0.777,0.726 and 0.930 in predicting the plaques of CHD patients.Conclusion:Hemodynamics and fat volume around heart that is measured by CCTA can predict coronary plaque,and there is a certain of relationship between coronary hemodynamics and the fat volume around coronary artery plaques,which appears negative correlation.