高龄女性卵母细胞内氧化应激与非整倍体相关性研究进展

Research Progress on the Correlation between Oxidative Stress and Aneuploidy in Oocytes of Aging Women

高龄女性的卵母细胞更易发生非整倍体。卵母细胞非整倍体是导致高龄女性生育力下降,出现流产、染色体异常、出生缺陷等不良妊娠结局的重要因素。随年龄增长,卵母细胞内活性氧(reactive oxygen species,ROS)不断积累,引起氧化应激(oxidative stress)损伤,干扰纺锤体组装和纺锤体组装检查点信号传导,并导致端粒缩短,降低染色体内聚力等,是造成高龄女性卵母细胞非整倍体率增加的重要原因。综述高龄女性卵母细胞内氧化应激与非整倍体的关系,以期为高龄女性生育力挽救提供依据。

The oocytes of aging women are more prone to aneuploidy.Oocyte aneuploidy is a significant factor contributing to the reduced fertility in aging women and the unfavorable pregnancy outcomes,including miscarriage,chromosomal abnormalities and birth defects.With the increase of age,the accumulation of reactive oxygen species(ROS)in oocytes causes the oxidative stress damage that interferes with the signal transduction of spindle assembly and spindle assembly checkpoints,shortens telomeres and reduces chromosome cohesion.The oxidative stress is therefore an important reason for the increase of aneuploidy of oocytes.We review the relationship between oxidative stress and aneuploidy in oocytes of aging women,in order to provide a reference for saving the fertility of aging women.