血清SCCA、ProGRP、NSE与老年非小细胞肺癌患者病理特征及化疗客观疗效的相关性分析

Correlation analysis of serum SCCA,ProGRP and NSE,pathological characteristics and objective response to chemotherapy in elderly patients with non-small cell lung cancer

目的 分析血清鳞状细胞癌抗原(SCCA)、胃泌素释放肽前体(ProGRP)、神经元特异性烯醇化酶(NSE)与老年非小细胞肺癌(NSCLC)患者病理特征及化疗客观疗效的相关性。方法 选取临泉县人民医院2020年10月~2023年5月收治的80例老年NSCLC患者,均接受规范化疗,根据化疗客观疗效分为部分缓解(PR)组、病情稳定(SD)组与疾病进展(PD)组,比较不同病理特征患者及不同化疗客观疗效组患者血清SCCA、ProGRP、NSE水平,并进行相关性分析。结果 Ⅳ分期、有淋巴结转移患者血清SCCA、ProGRP、NSE水平高于Ⅲ分期、无淋巴结转移患者,差异有统计学意义(P<0.05)。血清SCCA、ProGRP、NSE与患者TNM分期、淋巴结转移呈显著正相关(P<0.05)。PR组化疗后SCCA、ProGRP、NSE水平低于SD组、PD组,;SD组化疗后SCCA、NSE水平低于PD组,差异均有统计学意义(P<0.05)。化疗后,SCCA、ProGRP、NSE与化疗客观疗效呈显著负相关(P<0.05)。结论 血清SCCA、ProGRP、NSE与老年NSCLC患者TNM分期、淋巴结转移情况及化疗客观疗效密切相关。

Objective To analyze the correlation among serum squamous cell carcinoma antigen(SCCA),progastrin-releasing peptide(ProGRP)and neuron specific enolase(NSE),pathological characteristics and objective response to chemotherapy in elderly patients with non-small cell lung cancer(NSCLC).Methods 80 elderly patients with NSCLC who underwent standard chemotherapy in the hospital were selected and divided into partial remission(PR)group,stable disease(SD)group and progression of disease(PD)group according to the objective response to chemotherapy.Serum SCCA,ProGRP and NSE levels were compared among patients with different pathological characteristics and different objective responses to chemotherapy.Correlation analysis was conducted.Results Serum SCCA,ProGRP and NSE levels in patients at stage IV and with lymph node metastasis were higher than those in patients at stage III and without lymph node metastasis(P<0.05).Serum SCCA,ProGRP and NSE were positively correlated with TNM staging and lymph node metastasis(P<0.05).The levels of SCCA,ProGRP and NSE in PR group after chemotherapy were lower than those in SD group and PD group(P<0.05).The levels of SCCA and NSE in SD group after chemotherapy were lower than those in PD group(P<0.05).After chemotherapy,SCCA,ProGRP and NSE were negatively correlated with the objective response to chemotherapy(P<0.05).Conclusion Serum SCCA,ProGRP and NSE are closely related to TNM staging,lymph node metastasis and objective response to chemotherapy in elderly patients with NSCLC.