针刺治疗周围性面瘫的机制研究进展

Mechanism research progress in acupuncture treating peripheral facial paralysis

周围性面瘫是针灸临床常见的神经系统疾病,表现为颜面部一侧表情肌群运动功能障碍。近年来,该病发病率呈逐年上升趋势,严重影响人类的生活质量。既往临床研究发现,针刺在周围性面瘫不同阶段的治疗中均发挥积极的作用,但其作用机制尚未十分明确。该文收集整理了针刺治疗周围性面瘫的相关文献,从脑功能连接、脑功能可塑性、脑偏侧性、神经营养因子、黏附分子、局部微循环、神经结构及功能等方面梳理针刺干预潜在的中枢及外周机制,以期为日后临床研究及应用提供参考依据。

Objective Peripheral facial paralysis,manifesting as one side of motor dysfunction of facial expression muscles,is a common neurological disease in acupuncture-moxibustion clinics.Its incidence rate has been increasing in recent years,seriously affecting people’s quality of life.Previous studies have revealed the positive role of acupuncture in the treatment of peripheral facial paralysis in different stages,but the underlying mechanism is still unclear.Therefore,this article collected relevant studies to sort out potential central and peripheral mechanisms of acupuncture in treating peripheral facial paralysis from the aspects of brain functional connectivity,brain functional plasticity,brain lateralization,neurotrophic factors,adhesion molecules,local microcirculation,and nerve structure and function in order to provide references for future clinical research and application.