有氧运动治疗血管性痴呆的研究进展

Research progress of aerobic exercise in the treatment of vascular dementia

血管性痴呆(VD)是一种由脑血管因素引起的痴呆,主要表现为认知功能障碍。近年来,有氧运动作为一种非药物治疗手段,对VD的改善受到了广泛关注。本文综述了当前VD的临床干预情况、有氧运动改善VD的临床研究进展,以及有氧运动改善VD的基础实验进展,并重点探讨小胶质细胞及核因子-κB通路在有氧运动改善VD中的作用机制,旨在为今后VD的治疗研究提供参考。

Vascular dementia(VD)is a type of dementia caused by cerebrovascular factors,mainly manifested by cognitive dysfunction.In recent years,aerobic exercise as a non pharmacological treatment has received widespread attention in improving VD.This article reviews the current clinical interventions for VD,the clinical research progress of aerobic exercise in improving VD,and the basic experimental progress of aerobic exercise in improving VD.To investigate the mechanism of microglia and nuclear factor-κB pathway in the improvement of VD by aerobic exercise.Intended to provide reference for future research on the treatment of VD.