IL-25、PI3K信号通路在慢性阻塞性肺疾病中的研究进展

Research progress of IL-25 and PI3K signaling pathways in chronic obstructive pulmonary disease

慢性阻塞性肺疾病(COPD)作为一种全球性的健康负担,其高发病率、致残率及致死率已引起全球医疗界的广泛关注,随着人口老龄化、吸烟以及环境污染加剧,逐渐影响了患者的生活质量和社会经济负担。白细胞介素25(IL-25)作为一种细胞因子在多种生物学过程中发挥重要作用。研究表明,IL-25可以通过磷脂酰肌醇3-激酶(PI3K)信号传导途径来影响细胞的功能。具体来说,IL-25与细胞表面的受体结合后可以激活PI3K,进而引发一系列下游信号传导事件。因此,进一步深入研究IL-25、PI3K在COPD中的具体机制,对于开发新的治疗方法和改善COPD患者的预后具有重要意义。

Chronic obstructive pulmonary disease(COPD),as a global health burden,has attracted widespread attention from the global medical community due to its high morbidity,disability,and mortality.With the worsening of aging population,smoking problems,and environmental pollution,it has gradually affected the quality of life and social and economic burden of patients.Interleukin 25(IL25),as a cytokine,plays an important role in many biological processes.Studies have shown that IL25 can affect cell function through phosphatidylinositol 3kinase(PI3K)signal transduction pathway.Specifically,when IL25 binds to receptors on the cell surface,it can activate PI3K,which in turn triggers a series of downstream signal transduction events.Therefore,further study on the specific mechanism of IL25 and PI3K in COPD is of great significance for developing new treatment methods and improving the prognosis of COPD patients.