新癀片联合盐酸米诺环素软膏治疗牙周炎的临床疗效

Clinical Efficacy of Xinhuang Tablet Combined with Minocycline Hydrochloride Ointment in the Treatment of Periodontitis

目的 探讨牙周炎患者采用新癀片+盐酸米诺环素软膏治疗的效果。方法 选取2021年7月—2022年7月潍坊市第二人民医院收治的76例牙周炎患者为研究对象,治疗方法的不同分为两组,各38例。A组采用盐酸米诺环素软膏治疗;B组在A组治疗基础上加用新癀片。所有患者治疗时间均为4周。比较两组临床疗效、牙周指标、不良反应发生情况。结果 治疗后,两组不良反应总发生率比较,差异无统计学意义(P>0.05)。与治疗前比较,治疗后,两组患者龈沟出血指数、牙龈指数及菌斑指数评分均下降,且B组各指标评分均低于A组,差异有统计学意义(P均<0.05)。B组治疗总有效率为94.74%(36/38),高于A组的73.68%(28/38),差异有统计学意义(χ^(2)=6.333,P<0.05)。结论 牙周炎患者采用新癀片+盐酸米诺环素软膏治疗可改善其牙周指标,疗效显著,且未增加不良反应发生风险。

Objective To explore the effect of periodontitis patients treated with Xinhuang Tablet + minocycline hydrochloride ointment.Methods A total of 76 cases of periodontitis patients admitted to Weifang Second People's Hospital from July 2021 to July 2022 were selected as the study object,and were divided into two groups of 38 cases each by different treatment methods.Group A was treated with minocycline hydrochloride ointment,group B was treated on the basis of group A treatment + Xinhuang Tablet,and the treatment time of all patients was 4 weeks.Compared the clinical efficacy,periodontal indexes and occurrence of adverse reactions between the two groups.Results After treatment,the total incidence rate of adverse reactions in the two groups was compared,and the difference was not statistically significant(P>0.05).Compared with the pre-treatment,after treatment,the gingival sulcus bleeding index,gingival index and plaque index scores of the two groups decreased,and the scores of all indexes in group B were lower than those in group A,and the differences were statistically significant(all P<0.05).The total effective rate of treatment in group B was 94.74%(36/38),which was higher than 73.68%(28/38) in the group A,and the difference was statistically significant(χ^(2)=6.333,P<0.05).Conclusion Periodontitis patients can improve their periodontal indexes by adopting the treatment of Xinhuang Tablet + minocycline hydrochloride ointment with remarkable efficacy and without increasing the risk of adverse reactions.