新四联治疗慢性射血分数低下心力衰竭患者的效果分析

Analysis of the Effect of New Quadruple Therapy on Chronic Heart Failure with Reduced Ejection Fraction

目的分析临床治疗慢性射血分数低下心力衰竭患者时,使用新四联治疗方案的效果。方法方便选取2022年1月—2023年4月汶上县人民医院收治的92例慢性射血分数低下心力衰竭患者为研究对象,按照不同治疗方法分为对照组、观察组,每组46例。对照组使用“金三角”治疗方案,观察组使用新四联治疗方案。比较两组心功能指标、血浆脑钠肽、6 min步行试验距离、治疗效果、不良反应发生率。结果治疗后,观察组左室舒张末期内径、左室收缩末期内径分别为(31.24±4.74)mm、(37.33±6.91)mm,均低于对照组的(36.21±4.59)mm、(42.58±7.75)mm,左室射血分数为(56.02±6.48)%,高于对照组的(50.22±4.94)%,差异有统计学意义(t=5.109、3.429、4.828,P均<0.05)。治疗后,观察组血浆脑钠肽水平低于对照组,6 min步行试验距离长于对照组,差异有统计学意义(P均<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应发生率对比,差异无统计学意义(P>0.05)。结论慢性射血分数低下心力衰竭患者应用新四联治疗方案的效果较好,提高患者心功能,降低血浆脑钠肽水平。

Objective To analyze the effect of new quadruple therapy in the clinical treatment of patients with chronic heart failure with reduced ejection fraction.Methods A total of 92 patients with chronic heart failure with reduced ejection fraction admitted to Wenshang County People's Hospital from January 2022 to April 2023 were conveniently selected as the research objects.According to the different treatment method,they were divided into control group and observation group,with 46 cases in each group.The control group used the"Golden Triangle"treatment plan,and the observation group used the new quadruple treatment plan to observe.The cardiac function indexes,plasma brain natri-uretic peptide,6-minute walking test distance,treatment effect and incidence of adverse reactions were compared be-tween the two groups.Results After treatment,the left ventricular end-diastolic diameter and left ventricular end-systolic diameter were(31.24±4.74)mm,(37.33±6.91)mm,respectively in the observation,which group were lower than(36.21±4.59)mm,(42.58±7.75)mm in the control group,and the left ventricular ejection fraction was(56.02±6.48)%,whichwas higher than(50.22±4.94)%in the control group,the differences were statistically significant(t=5.109,3.429,4.828,all P<0.05).After treatment,the level of plasma brain natriuretic peptide in the observation group was lower than that in the control group,and the 6-minute walking test distance was longer than that in the control group,the differences were statistically significant(both P<0.05).The total effective rate of treatment in the observa-tion group was higher than that of the control group,the different was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The effect of new quadruple therapy in patients with chronic heart failure with low ejection fraction is better,which can improve the cardiac function and reduce the level of plasma brain natriuretic peptide.