对比耐药性肺结核采用左氧氟沙星与莫西沙星的治疗效果

To Compare the Efficacy of Levofloxacin and Moxifloxacin in the Treatment of Drug-resistant Tuberculosis

目的分析左氧氟沙星与莫西沙星治疗耐药性肺结核的临床疗效。方法方便选取2021年12月—2023年12月宿迁市传染病医院收治的72例耐药性肺结核患者为研究对象,按照不同用药方案分为两组,各36例,两组予以基础药物干预,对照组增加左氧氟沙星治疗,研究组增加盐酸莫西沙星片治疗。对比两组疗效、炎症因子、不良反应发生率、免疫功能和肺功能指标。结果研究组治疗总有效率为94.45%(34/36),高于对照组的77.77%(28/36),差异有统计学意义(χ^(2)=4.181,P=0.041)。治疗后,研究组炎症因子水平和不良反应总发生率均低于对照组,免疫功能指标水平优于对照组,用力肺活量、每秒呼气峰流速和每分钟最大通气量均高于对照组,差异有统计学意义(P均<0.05)。结论相比左氧氟沙星,莫西沙星更利于减轻耐药性肺结核疾病负担,改善肺功能,提高疗效,促进早日康复。

Objective To analyze the clinical efficacy of levofloxacin and moxifloxacin in the treatment of drug-resistant tuberculosis.Methods A total of 72 patients with drug-resistant pulmonary tuberculosis admitted to Suqian Infectious Disease Hospital from December 2021 to December 2023 were conveniently selected as the research ob-jects.They were divided into two groups according to different medication regimens,36 cases in each group.The two groups were given basic drug intervention.The control group was treated with levofloxacin,and the study group was treated with moxifloxacin hydrochloride tablets.The efficacy,inflammatory factors,incidence of adverse reactions,im-mune function and lung function indexes were compared between the two groups.Results The total effective rate of treatment in the study group was 94.45%(34/36)higher than that in the control group 77.77%(28/36),and the differ-ence was statistically significant(χ^(2)=4.181,P=0.041).After treatment,the level of inflammatory factors and total inci-dence of adverse reactions in the study group were lower than those in the control group,the immune function index level was better than that of the control group.the forced vital capacity,peak expiratory flow per second and maximum ventilation per minute were higher than those in the control group,the differences were statistically significant(all P<0.05).Conclusion Compared with levofloxacin,moxifloxacin is more beneficial to reduce the disease burden of drug-resistant tuberculosis,improve lung function,improve curative effect and promote early recovery.