左炔诺孕酮宫内缓释系统预防子宫内膜息肉宫腔镜手术后复发的效果及其对子宫内膜厚度的影响

The Effect of Levonorgestrel-releasing Intrauterine System on Preventing Recurrence of Endometrial Polyps after Hysteroscopic Surgery and its Effect on Endometrial Thickness

目的分析左炔诺孕酮宫内缓释系统预防子宫内膜息肉宫腔镜手术后复发的效果及其对子宫内膜厚度的影响。方法回顾性选取2021年7月—2023年12月漳州市云霄县医院接受子宫内膜息肉宫腔镜手术的96例患者的临床资料,按照不同的治疗方式分为对照组和观察组,各48例。对照组在宫腔镜手术后使用地屈孕酮片治疗,观察组使用左炔诺孕酮宫内缓释系统。对比两组的月经量、月经周期、子宫内膜厚度、雌激素水平及复发率情况。结果治疗后,观察组月经量失血图评分、子宫内膜厚度均低于对照组,月经周期短于对照组,差异有统计学意义(P均<0.05)。治疗后,两组雌激素水平比较,差异无统计学意义(P>0.05)。观察组治疗6个月后的复发率为2.08%(1/48),低于对照组的16.67%(8/48),差异有统计学意义(χ^(2)=6.008,P<0.05)。结论在子宫内膜息肉的治疗中,采用宫腔镜手术后联合使用左炔诺孕酮宫内缓释系统治疗具有一定的优势,能够降低复发率,控制月经失血量、降低子宫内膜厚度,对患者的雌激素水平影响较小。

Objective To analyze the effect of levonorgestrel-releasing intrauterine system on preventing recurrence of endometrial polyps after hysteroscopic surgery and its effect on endometrial thickness.Methods The clinical data of 96 patients who underwent hysteroscopic surgery for endometrial polyps in Zhangzhou Yunxiao County Hospital from July 2021 to December 2023 were retrospectively selected.According to different treatment methods,they were di-vided into control group and observation group,with 48 cases in each group.The control group was treated with dydro-gesterone tablets after hysteroscopic surgery,and the observation group was treated with levonorgestrel-releasing intra-uterine system.The menstrual volume,menstrual cycle,endometrial thickness,estrogen level and recurrence rate were compared between the two groups.Results After treatment,the scores of menstrual blood loss and endometrial thick-ness in the observation group were lower than those in the control group,and the menstrual cycle was shorter than that in the control group,the differences were statistically significant(all P<0.05).After treatment,there was no significant difference in extrogen levels between the two groups(P>0.05).The recurrence rate of the observation group after 6 months of treatment was 2.08%(1/48),which was lower than 16.67%(8/48)of the control group,and the difference was statistically significant(χ^(2)=6.008,P<0.05).Conclusion In the treatment of endometrial polyps,hysteroscopic sur-gery combined with levonorgestrel-releasing intrauterine system has certain advantages,which can reduce the recur-rence rate,control menstrual blood loss,reduce endometrial thickness,and have little effect on the estrogen level of patients.