大黄复方灌肠对慢性肾脏病3~5期(非透析)疗效和对肠道菌群的影响

Influence of Rhubarb Compound Enema on Effect of Stage 3-5(Non dialysis)and Intestinal Flora in CKD

目的评析慢性肾脏病3~5期(非透析)患者应用大黄复方灌肠治疗的效果,以及对肠道菌群的影响。方法随机选取2022年1月—2023年12月如东县中医院接诊的80例慢性肾脏病3~5期(非透析)患者为研究对象,根据不同治疗方法分为对照组和观察组,每组40例。对照组采用常规治疗,观察组在常规治疗基础上用大黄复方灌肠治疗,比较两组患者肠道菌群情况、中医证候积分、肾功能情况。结果治疗后,观察组大肠杆菌指标(2.81±0.55)log10低于对照组的(3.35±0.54)log10,双歧杆菌(3.99±0.15)log10及乳酸杆菌指标(3.88±0.49)log10均高于对照组的(2.79±1.05)log10、(3.33±0.37)log10,差异有统计学意义(t=2.215、3.578、2.833,P均<0.05)。治疗后,观察组中医证候积分低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组肾功能指标低于对照组,但差异无统计学意义(P>0.05)。结论慢性肾脏病3~5期(非透析)应用大黄复方灌肠治疗的效果显著,可以改善肠道菌群。

Objective To assess the efficacy of rhubarb compound enema in treating chronic renal disease stage 3-5(Non-dialysis)and Influence on Gut Flora.Methods A total of 80 patients with stage 3-5 chronic kidney disease(Non-dialysis)admitted to Rudong County Hospital of Traditional Chinese Medicine from January 2022 to December 2023 were randomly selected as the research objects,and were divided into control group and observation group ac-cording to different treatment methods,with 40 cases in each group.The control group was treated with routine treat-ment,and the observation group was treated with rhubarb compound enema on the basis of routine treatment.The in-testinal flora,traditional Chinese medicine(TCM)syndrome score and renal function were compared between patients in two groups.Results After treatment,the Escherichia coli index(2.81±0.55)log10 in the observation group was lower than that in the control group(3.35±0.54)log10,Bifidobacterium(3.99±0.15)log10 and Lactobacillus index(3.88±0.49)log10 were higher than those in the control group(2.79±1.05)log10,(3.33±0.37)log10,the differences were statistically significant(t=2.215,3.578,2.833,all P<0.05).After tratment the scores of TCM syndromes in the ob-servation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Af-ter tratment the renal function index of the observation group was lower than that of the control group,but the differ-ence was not statistically significant(P>0.05).Conclusion The efficacy of rhubarb compound enema for patients with chronic renal disease stage 3-5(Non-dialysis)was significant,and could improve the gut flora.