肠道微生物及其代谢物在急性脑卒中中的作用及机制

Role and Mechanism of Gut Microbiota and Its Metabolites in Acute Stroke

急性脑卒中是我国致死率较高的疾病,其病因主要包括高血压、动脉粥样硬化、动脉瘤破裂等。而肠道微生物群及其代谢物与脑血管疾病密切相关。其中,三甲胺-N-氧化物、苯乙酰谷氨酰胺可促进血栓形成,而5-羟色胺可影响脑卒中的发生发展,脂多糖、短链脂肪酸则可激活炎症反应,而炎症反应参与了脑卒中的发生发展及治疗的全过程。因此,全面了解肠道微生物及其代谢物在脑卒中中的作用机制,可以为脑卒中的治疗和预防提供新思路。

Acute stroke is a disease with a high mortality rate in China.Its causes mainly include hypertension,atherosclerosis,aneurysm rupture,etc.The gut microbiota and its metabolites are closely related to cerebrovascular diseases.Among them,trimethylamine-N-oxide and phenylacetylglutamine can promote thrombosis,while 5-hydroxytryptamine can affect the occurrence and development of stroke.Lipopolysaccharides and short chain fatty acids can activate inflammatory responses,which are involved in the entire process of stroke occurrence,development,and treatment.Therefore,a comprehensive understanding of the mechanism of action of gut microbiota and its metabolites in stroke can provide new ideas for the treatment and prevention of stroke.