西药联合固冲汤治疗异常子宫出血疗效及对患者临床症状改善和预后的影响

Effect of Guchong decoction for treating patients with abnormal uterine bleeding and its influence on the improvement of clinical symptoms and prognosis

目的:探究固冲汤加减辅助治疗异常子宫出血对患者临床症状改善及预后影响。方法:选取2021年1月-2023年9月本院门诊收治的异常子宫出血患者102例,采用双色球法分为对照组和观察组各51例,两组均给予地屈孕酮片治疗,观察组同时联合固冲汤加减治疗,均治疗6个月经周期,并接受6个月随访。对比两组疗效、促卵泡生成素(FSH)、雌二醇(E_(2))及孕酮(P)水平、子宫内膜厚度、不良反应、复发及预后生活质量。结果:治疗后观察组治疗有效率(94.1%)高于对照组(78.4%),两组E_(2)均升高,FSH、P均降低,且观察组变化幅度大于对照组,两组子宫内膜厚度均降低,且观察组内膜厚度(0.78±0.19cm)低于对照组(1.09±0.24cm),不良反应发生率(9.8%)低于对照组(27.5%),两组生存质量测定量表汉化版(WHOQOL-BREF)评分均升高,且观察组(90.10±1.73分)高于对照组(84.56±2.95分),复发率(6.0%)低于对照组(23.5%)(均P<0.05)。结论:应用西药联合固冲汤加减方治疗异常子宫出血,可显著提升临床疗效,改善患者性激素水平及子宫内膜厚度,提升预后生活质量,降低复发率。

Objective:To explore the effects of the Guchong decoction plus or minus for treating patients with abnormal uterine bleeding on the improvement of their clinical symptoms and prognosis.Methods:A total of 102 patients with abnormal uterine bleeding who received outpatient treatment were selected and were divided into two groups(51 cases in each group)by bicolor sphere method from January 2021 to September 2023.The patients in the two groups were given dydrogesterone tablets for 6 menstrual cycles,and the patients in the study group were given Guchong decoction plus or minus additionally.The patients in both groups received 6 months of follow-up.The efficacy,the levels of the follicle stimulating hormone(FSH),estradiol(E_(2))and progesterone(P),the endometrial thickness,the rates of adverse reactions and abnormal uterine bleeding recurrence,and the prognostic quality of life of the patients were compared between the two groups.Results:The efficient rate(94.1%)of the patients in the study group after treatment was significantly higher than that(78.4%)of the patients in the control group.The E_(2)level of the patients in both groups had increased significantly and the levels of FSH and P of the patients in both groups had decreased significantly,and the variations of which of the patients in the study group were significantly more than those of the patients in the control group.The endometrium thickness of the patients in both groups had decreased significantly,and which(0.78±0.19cm)of the patients in the study group was significantly lower than that(1.09±0.24cm)of the patients in the control group.The incidence of adverse reactions(9.8%)of the patients in the study group was significantly lower than that(27.5%)of the patients in the control group,and the score of the Chinese version of world health organization quality of life scale(WHOQOL-BREF)of the patients in both groups had increased significantly,and which(90.10±1.73points)of the patients in the study group was significantly higher than that(84.56±2.95points)of the patients in the control group.The recurrence rate of abnormal uterine bleeding(6.0%)of the patients in the study group was significantly lower than that(23.5%)of the patients in the control group(all P<0.05).Conclusion:Guchong decoction plus or minus for treating patients with abnormal uterine bleeding can significantly improve the clinical therapeutic effect,the sex hormone levels and the endometrial thickness,increase the prognosis quality of life and reduce the recurrence rate of abnormal uterine bleeding of the patients.