阴道超声联合血清β-hCG、孕酮水平诊断异位妊娠价值

Value of the vaginal ultrasound combined with the serum human chorionic gonadotropinβand progesterone levels of women for diagnosing their ectopic pregnancy

目的:探究阴道超声联合血清人绒毛膜促性腺激素β(β-hCG)、孕酮(P)在异位妊娠诊断中的价值。方法:回顾性分析2019年1月-2023年6月本院109例经病理检测证实的异位妊娠患者临床资料设为异位妊娠组,同期产前检查正常孕妇70例为正常妊娠组,两组入院后均行超声检查和血清β-hCG、P检测,比较两组超声检测结果及血清β-hCG、P水平,Pearson相关性分析血清β-hCG、P与超声检测指标的相关性,采用受试者工作特征(ROC)曲线分析血清β-hCG、P水平及子宫内膜厚度对异位妊娠的诊断价值。结果:异位妊娠组子宫内膜厚度、血清β-hCG及P水平均低于正常妊娠组,包块最大直径、血流阻力指数(RI)高于正常妊娠组,异位妊娠患者血清β-hCG、P水平与子宫内膜厚度呈正相关,与包块最大直径、RI呈负相关(均P<0.05);子宫内膜厚度、血清β-hCG及P水平单独及联合诊断异位妊娠的曲线下面积分别为0.841、0.701、0.904、0.970,敏感度为72.5%、69.7%、86.2%、94.3%,特异度为81.4%、68.6%、72.9%、81.5%,联合诊断价值更高。结论:超声联合血清β-hCG、P检测诊断异位妊娠临床效能较高,可用于异位妊娠临床早期筛查。

Objective:To explore the value of the vaginal ultrasound combined with the serum human chorionic gonadotropinβ(β-HCG)and progesterone(P)levels of women for diagnosing their ectopic pregnancy.Methods:The clinical data of 109 women with ectopic pregnancy(in study group)confirmed by the pathological examination in the hospital from January 2019 to June 2023 were analyzed retrospectively,and 70 normal pregnant women who came to the hospital for physical examination were selected in control group during the same period.The women in the two groups after admission in the hospital were given ultrasound examination and the serumβ-HCG and P levels detections.The ultrasound results and the serumβ-HCG and P levels of the women were compared between the two groups.The correlation analysis was used to analyze the correlation between the serumβ-HCG and P of the women and their ultrasound indicators values.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic values of the serumβ-HCG and P levels and the endometrial thickness for their ectopic pregnancy.Results:The endometrial thickness,the serumβ-HCG and P levels of the women in the study group were significantly lower than those of the women in the control group,and the maximum diameter of the mass and the blood flow resistance index(RI)value of the women in the study group were significantly higher than those of the women in the control group.The serumβ-HCG and P levels of the women with ectopic pregnancy were positively correlated with their endometrial thickness,and were negatively correlated with the maximum diameter of the mass and the RI value of the women(all P<0.05).The area under the curve of the endometrial thickness,the serumβ-HCG level,the P level,or the combined the endometrial thickness and the serum levels of serumβ-HCG and P of the women for diagnosing their ectopic pregnancy were 0.841,0.701,0.904,0.970,respectively,the sensitivity of which were 72.5%,69.7%,86.2%,94.3%,respectively and the specificity of which were 81.4%,68.6%,72.9%,81.5%,,respectively.The combined the endometrial thickness and the serum levels of serumβ-HCG and P of the women for diagnosing their ectopic pregnancy had the higher diagnostic value.Conclusion:The combined the endometrial thickness and the serum levels of serumβ-HCG and P of the women for diagnosing their ectopic pregnancy has the higher clinical diagnostic efficacy,and which can be used for the early clinical screening the ectopic pregnancy of the women.